2. Academic Validation
  3. Immunosuppressive activity of 8-gingerol on immune responses in mice

Immunosuppressive activity of 8-gingerol on immune responses in mice

  • Molecules. 2011 Mar 22;16(3):2636-45. doi: 10.3390/molecules16032636.
Jing Lu 1,  Shuang Guan,  Xue Shen,  Wenhui Qian,  Guoren Huang,  Xuming Deng,  Guanghong Xie
Affiliations

Affiliation

  • 1 Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China.
PMID: 21441866 DOI: 10.3390/molecules16032636
Abstract

8-gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only significantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-specific IgG, IgG1 and IgG2B levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.

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