2. Academic Validation
  3. Streptothricin derivatives from Streptomyces sp. I08A 1776

Streptothricin derivatives from Streptomyces sp. I08A 1776

  • J Nat Prod. 2011 May 27;74(5):1142-7. doi: 10.1021/np2000733.
Maoluo Gan 1,  Xudong Zheng,  Lishe Gan,  Yan Guan,  Xueqin Hao,  Yishuang Liu,  Shuyi Si,  Yuqin Zhang,  Liyan Yu,  Chunling Xiao
Affiliations

Affiliation

  • 1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
PMID: 21510638 DOI: 10.1021/np2000733
Abstract

Five new streptothricin derivatives with a carbamoyl group substituted at C-12 (1-5) and three known analogues have been isolated from the culture broth of Streptomyces sp. I08A 1776 by ion exchange and hydrophilic interaction chromatographic techniques. Their structures were determined by spectroscopic and chemical methods. Compound 3 was a streptothricin derivative possessing a cis-streptolidine moiety. Its absolute configuration was defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Compound 5 and streptothricin E (6) displayed Antibacterial and Antifungal activity with MIC values in the range 1-64 μg/mL.

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