2. Academic Validation
  3. (-)-Duryne and its homologues, cytotoxic acetylenes from a marine Sponge Petrosia sp

(-)-Duryne and its homologues, cytotoxic acetylenes from a marine Sponge Petrosia sp

  • J Nat Prod. 2011 May 27;74(5):1262-7. doi: 10.1021/np200271n.
Yuki Hitora 1,  Kentaro Takada,  Shigeru Okada,  Yuji Ise,  Shigeki Matsunaga
Affiliations

Affiliation

  • 1 Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8657, Japan.
PMID: 21534590 DOI: 10.1021/np200271n
Abstract

Six linear acetylenes, (-)-duryne (1) and (-)-durynes B-F (2-6), were isolated from the marine Sponge Petrosia sp. Their structures were elucidated by NMR and tandem FABMS analyses. The positions of the olefinic bonds were confirmed by ozonolysis experiments, and the absolute configurations were determined by the modified Mosher's method. Compound 1 was found to be the enantiomer of duryne, a previously reported Sponge metabolite. Compounds 1-6 show cytotoxicity against HeLa cells with IC50 values between 0.08 and 0.50 μM.

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