2. Academic Validation
  3. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum

Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum

  • J Nat Med. 2012 Apr;66(2):362-6. doi: 10.1007/s11418-011-0581-3.
De-Wu Zhang 1,  Yan Yang,  Fang Yao,  Qun-Ying Yu,  Sheng-Jun Dai
Affiliations

Affiliation

  • 1 School of Pharmaceutical Science, Yantai University, 264005 Yantai, People's Republic of China.
PMID: 21898133 DOI: 10.1007/s11418-011-0581-3
Abstract

A new coumestan (solalyratin A, 1) and a novel cyclic eight-membered α,β-unsaturated ketone (solalyratin B, 3), together with three known compounds, puerariafuran (2), coumestrol (4) and 9-hydroxy-2',2'-dimethylpyrano[5',6':2,3]-coumestan (5), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of spectroscopic analyses. In vitro, compounds 1-5 showed anti-inflammatory activities, with IC(50) values in the range 6.3-9.1 μM.

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