2. Academic Validation
  3. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

  • EMBO Rep. 2011 Oct 28;12(11):1160-6. doi: 10.1038/embor.2011.184.
Weixiang Wang 1,  Zhi Chen,  Zhuo Mao,  Huihui Zhang,  Xiaojun Ding,  She Chen,  Xiaodong Zhang,  Ruiming Xu,  Bing Zhu
Affiliations

Affiliation

  • 1 Chromatin Lab, National Institute of Biological Sciences, 7 Science Park Road, Zhong Guan Cun Life Science Park, Beijing 102206, China.
PMID: 21960006 DOI: 10.1038/embor.2011.184
Abstract

The tandem Tudor-like domain-containing protein Spindlin1 has been reported to be a meiotic spindle-associated protein. Here we report that Spindlin1 is not associated with the spindle in mouse embryonic fibroblast cells during mitotic divisions. In interphase cells, Spindlin1 specifically localizes to the nucleoli. Moreover, Spindlin1 is a histone methylation effector protein that specifically recognizes H3K4 methylation. Finally, Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of rRNA genes.

Figures