2. Academic Validation
  3. Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages

Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages

  • Bioorg Med Chem Lett. 2012 Feb 15;22(4):1615-8. doi: 10.1016/j.bmcl.2011.12.122.
Sa Deng 1,  Bao Jing Zhang,  Chang Yuan Wang,  Yan Tian,  Ji Hong Yao,  Lei An,  Shan Shan Huang,  Jin Yong Peng,  Ke Xin Liu,  Xiao Chi Ma
Affiliations

Affiliation

  • 1 School of Pharmaceutical Sciences, Dalian Medical University, Dalian 116044, PR China.
PMID: 22264489 DOI: 10.1016/j.bmcl.2011.12.122
Abstract

A series of analogues of deoxyandrographolide (1) transformed by Cunninghamella blakesleana AS 3.2004 were isolated and identified by spectral methods including 2D NMR. Among them, 3-oxo-17,19-dihydroxy-7,13-ent-labdadien-15,16-olide (9), 3-oxo-19-hydroxy-1,13-ent-labdadien-15,16-olide (16), 3-oxo-1β-hydroxy-14-deoxy-andrographolide (17) and 3-oxo-2β-hydroxy-14-deoxyandrographolide (18) are new compounds. And their structure-activity relationships (SAR) of inhibitory activity on LPS-induced NO production in RAW 264.7 macrophage cells were also discussed.

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