2. Academic Validation
  3. Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives

Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives

  • Bioorg Med Chem Lett. 2012 May 1;22(9):3191-3. doi: 10.1016/j.bmcl.2012.03.043.
Zhenhua Luo 1,  Baoquan Chen,  Shuangyan He,  Yanping Shi,  Yuming Liu,  Caiwen Li
Affiliations

Affiliation

  • 1 Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China.
PMID: 22483583 DOI: 10.1016/j.bmcl.2012.03.043
Abstract

A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research.

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