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  2. 4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis

4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis

  • FEBS Lett. 2012 Jun 21;586(13):1778-82. doi: 10.1016/j.febslet.2012.04.060.
Shingo Miyata 1 Jun Inoue Makoto Shimizu Ryuichiro Sato
Affiliations

Affiliation

  • 1 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Abstract

Sterol regulatory element-binding proteins (SREBPs) are major transcription factors that regulate the expression of genes involved in fatty acid and Cholesterol biosynthesis. Here we show that 4'-hydroxyflavanone (4'-HF) impairs the fatty acid synthase promoter activity and reduces the activation of SREBPs and their target gene expression in human hepatoma Huh-7 cells. Moreover, 4'-HF suppresses de novo fatty acid and Cholesterol synthesis. This study identifies 4'-HF as an inhibitor of SREBP maturation and lipid synthesis, and provides evidence that 4'-HF may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia.

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