2. Academic Validation
  3. Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents

Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents

  • Bioorg Med Chem Lett. 2012 Sep 1;22(17):5424-7. doi: 10.1016/j.bmcl.2012.07.041.
Ravindra M Kumbhare 1,  Umesh B Kosurkar,  M Janaki Ramaiah,  Tulshiram L Dadmal,  S N C V L Pushpavalli,  Manika Pal-Bhadra
Affiliations

Affiliation

  • 1 Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India. rakumbhare@yahoo.com
PMID: 22858144 DOI: 10.1016/j.bmcl.2012.07.041
Abstract

A new series of isoxazoles and triazoles linked 2-phenyl benzothiazole were synthesized and evaluated for their Anticancer activity. These compounds have been tested for their cytotoxicity three Cancer cell lines. Among the compounds tested, compound 5d showed good cytotoxicity against Colo-205 and A549 cells in comparison to standard control PMX 610(1). Further compound 5d has been tested for its apoptotic activity and its inhibitory activity against Caspase and PARP proteins. Hence this compound has the potential that it can be selected for further biological studies.

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