2. Academic Validation
  3. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs

Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs

  • Biol Pharm Bull. 2012;35(8):1295-9. doi: 10.1248/bpb.b12-00145.
Pei Yu 1,  Longfei Xia,  Jing Zhao,  Gaoxiao Zhang,  Zaijun Zhang,  Ming Lang,  Yuqiang Wang
Affiliations

Affiliation

  • 1 Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China.
PMID: 22863928 DOI: 10.1248/bpb.b12-00145
Abstract

We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their Anticancer activity in Cell Culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.

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