2. Academic Validation
  3. Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity

Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity

  • Eur J Med Chem. 2013 Jan:59:7-14. doi: 10.1016/j.ejmech.2012.10.046.
Surbhi Arya 1,  Nikhil Kumar,  Partha Roy,  S M Sondhi
Affiliations

Affiliation

  • 1 Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667 UK, India.
PMID: 23202484 DOI: 10.1016/j.ejmech.2012.10.046
Abstract

2-Cyanopyridine (1a), 4-cyanopyridine (1b), 2-cyanopyrazine (1c) on condensation with mono amines (2a-c) and diamines (4a-c) in the presence of sodium methoxide as catalyst gave amidine derivatives (3a-i) and bis amidine derivatives (5a-i) in good yields. All these compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory activity and for in vitro Anticancer activity compounds 5c and 5d exhibited good anti-inflammatory activity whereas compounds 5d breast (T47D), 5h, 5i lung (NCI H-522), 5i colon (HCT-15), 3c, 3h, 5i ovary (PA-1) and 3c, 5b, 5h liver (HepG2) exhibited good Anticancer activity.

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