2. Academic Validation
  3. Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities

Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities

  • Phytochemistry. 2013 Sep:93:203-9. doi: 10.1016/j.phytochem.2013.03.008.
Si Chen 1,  Hung-Yi Huang,  Ming-Jen Cheng,  Chin-Chung Wu,  Tsutomu Ishikawa,  Chien-Fang Peng,  Hsun-Shou Chang,  Chyi-Jia Wang,  Su-Ling Wong,  Ih-Sheng Chen
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
PMID: 23582215 DOI: 10.1016/j.phytochem.2013.03.008
Abstract

Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallylcatechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 2.1, and 5.3 μM, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H37Rv, with MIC values of 30.3, 27.6, and 25.5 μg/mL, respectively.

Keywords

Antiplatelet activity; Antitubercular activity; Neolignan; Phenylpropanoid; Piper taiwanense; Piperaceae; Root.

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