4-Allylcatechol (Synonyms: Hydroxychavicol; 4-Allylpyrocatechol)

Name: 4-Allylcatechol
Brand: MedChemExpress
SKU: HY-N1887
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1887 Purity: 99.73%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

4-Allylcatechol (4-Allylpyrocatechol) is a xylan which has oral activity and can be isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC₅₀ = 5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC = 27.6 μg/mL).

For research use only. We do not sell to patients.

4-Allylcatechol Chemical Structure

CAS No. : 1126-61-0

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE 4-Allylcatechol

•ACS Omega. 2024 Feb 28;9(10):11870-11882. [Abstract]

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

View All TNF Receptor Isoform Specific Products:

View All Isoforms

TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All Interleukin Related Isoform Specific Products:

View All Isoforms

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	83 μM Compound: HC, Hydroxychavicol	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 24508612]
HepG2	IC₅₀	> 30 μM Compound: 1	Growth inhibition of human HepG2 cells after 72 hrs by MTT assay Growth inhibition of human HepG2 cells after 72 hrs by MTT assay	[PMID: 25559204]
HL-60	IC₅₀	3 μM Compound: 1	Growth inhibition of human HL60 cells after 72 hrs by MTT assay Growth inhibition of human HL60 cells after 72 hrs by MTT assay	[PMID: 25559204]
HL-60	IC₅₀	50 μM Compound: 1	Growth inhibition of human HL60 cells after 24 hrs by MTT assay Growth inhibition of human HL60 cells after 24 hrs by MTT assay	[PMID: 25559204]
MCF7	IC₅₀	> 30 μM Compound: 1	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay Growth inhibition of human MCF7 cells after 72 hrs by MTT assay	[PMID: 25559204]
MIA PaCa-2	IC₅₀	> 30 μM Compound: 1	Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTT assay Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTT assay	[PMID: 25559204]
PC-3	IC₅₀	55 μM Compound: HC, Hydroxychavicol	Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 24508612]
SK-N-SH	IC₅₀	> 30 μM Compound: 1	Growth inhibition of human SK-N-SH cells after 72 hrs by MTT assay Growth inhibition of human SK-N-SH cells after 72 hrs by MTT assay	[PMID: 25559204]

In Vitro

4-Allylcatechol (IC₅₀ = 5.3 µM，MIC = 27.6 μg/mL) exhibits strong antiplatelet aggregation and antitubercular activity^[1].
4-Allylcatechol (IC₅₀ = 99.83 µM) exhibits cytotoxicity in HT29 cells^[2].
4-Allylcatechol (100 μg/mL, 30 min) demonstrates potent antioxidant activity, with a radical scavenging rate of 77.05%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	HT29 cells (Colon cancer)
Concentration:	62.5 μM to 1mM
Incubation Time:	24 hours
Result:	Showed an IC₅₀ of 99.89 μM (15.0 µg/mL).

In Vivo

4-Allylcatechol (2-4 mg/kg, p.o., once daily for 21 days) effectively reduces cognitive deficits and mitigates oxidative stress and inflammation in Streptozotocin (HY-13753)-induced rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Alzheimer’s disease (AD) model induced by Streptozotocin (HY-13753) in rats^[4]
Dosage:	0.5, 1, 2, 4 mg/kg
Administration:	Oral gavage (p.o.), once daily for 21 days
Result:	Significantly improved cognitive function, decreased levels of TNF-α, IL-1β, IL-6, and reduced lipid peroxidation (MDA) in brain tissue.

Molecular Weight

150.17

Formula

C₉H₁₀O₂

CAS No.

1126-61-0

Appearance

Solid

Color

Light yellow to brown

SMILES

OC1=CC=C(CC=C)C=C1O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (665.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6591 mL	33.2956 mL	66.5912 mL
5 mM	1.3318 mL	6.6591 mL	13.3182 mL
10 mM	0.6659 mL	3.3296 mL	6.6591 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (246 KB) LCMS (257 KB)

Handling Instructions (2659 KB)

References

[1]. Chen S, et al. Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities[J]. Phytochemistry, 2013, 93: 203-209. [Content Brief]

[2]. Ng PL, et al. Piper betle leaf extract enhances the cytotoxicity effect of 5-fluorouracil in inhibiting the growth of HT29 and HCT116 colon cancer cells. J Zhejiang Univ Sci B. 2014 Aug;15(8):692-700. [Content Brief]

[3]. Annavarapu T, et al. Anti-inflammatory and antioxidant activities of 4-allylpyrocatechol and its derivatives with molecular docking and ADMET investigations[J]. Bulletin of the karaganda university chemistry series, 2022, 1(105): 50-59.

[4]. Pandey A, et al. Hydroxychavicol inhibits immune responses to mitigate cognitive dysfunction in rats. J Neuroimmunol. 2010 Sep 14;226(1-2):48-58. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.6591 mL	33.2956 mL	66.5912 mL	166.4780 mL
	5 mM	1.3318 mL	6.6591 mL	13.3182 mL	33.2956 mL
	10 mM	0.6659 mL	3.3296 mL	6.6591 mL	16.6478 mL
	15 mM	0.4439 mL	2.2197 mL	4.4394 mL	11.0985 mL
	20 mM	0.3330 mL	1.6648 mL	3.3296 mL	8.3239 mL
	25 mM	0.2664 mL	1.3318 mL	2.6636 mL	6.6591 mL
	30 mM	0.2220 mL	1.1099 mL	2.2197 mL	5.5493 mL
	40 mM	0.1665 mL	0.8324 mL	1.6648 mL	4.1619 mL
	50 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3296 mL
	60 mM	0.1110 mL	0.5549 mL	1.1099 mL	2.7746 mL
	80 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0810 mL
	100 mM	0.0666 mL	0.3330 mL	0.6659 mL	1.6648 mL

4-Allylcatechol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

4-Allylcatechol (Synonyms: Hydroxychavicol; 4-Allylpyrocatechol)

Customer Review

4-Allylcatechol Related Antibodies

1 Publications Citing Use of MCE 4-Allylcatechol

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All TNF Receptor Isoform Specific Products:

View All Interleukin Related Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

4-Allylcatechol Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

4-Allylcatechol Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report