2. Academic Validation
  3. Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors

Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors

  • Bioorg Med Chem. 2013 Nov 1;21(21):6282-91. doi: 10.1016/j.bmc.2013.08.067.
Tzung-Sheng Lin 1,  Ya-Wen Liw,  Jen-Shin Song,  Tsung-Chih Hsieh,  Hsien-Wei Yeh,  Lih-Ching Hsu,  Chun-Jung Lin,  Szu-Huei Wu,  Pi-Hui Liang
Affiliations

Affiliation

  • 1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
PMID: 24071445 DOI: 10.1016/j.bmc.2013.08.067
Abstract

Novel C-aryl-d-glucofuranosides were synthesized and evaluated for their capacity to inhibit human sodium-dependent glucose co-transporter 2 (hSGLT2) and hSGLT1. Compound 21q demonstrated the best in vitro inhibitory activity against SGLT2 in this series (EC50=0.62μM).

Keywords

Antidiabetics; Glucofuranosides; SGLT.

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