2. Academic Validation
  3. Trinorditerpenes from the roots of Flueggea virosa

Trinorditerpenes from the roots of Flueggea virosa

  • Bioorg Med Chem Lett. 2014 Jan 15;24(2):447-9. doi: 10.1016/j.bmcl.2013.12.051.
Chih-Hua Chao 1,  Ju-Chien Cheng 2,  Tsong-Long Hwang 3,  De-Yang Shen 4,  Tian-Shung Wu 5
Affiliations

Affiliations

  • 1 School of Pharmacy, China Medical University, Taichung 404, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. Electronic address: chaochihhua@hotmail.com.
  • 2 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan.
  • 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
  • 4 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
  • 5 Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.
PMID: 24388689 DOI: 10.1016/j.bmcl.2013.12.051
Abstract

Two trinorditerpenes, flueggrenes A and B (1 and 2), have been isolated from the roots of Flueggea virosa. Their structures were established by extensive analyses of spectroscopic data. The isolates were evaluated for anti-HCV activity, as well as the inhibition of superoxide anion generation and Elastase release in response to FMLP/cytochalasin B.

Keywords

Anti-HCV; Flueggea virosa; Flueggrene A; Flueggrene B.

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