2. Academic Validation
  3. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells

Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells

  • Cell Biol Int. 2014 Jul;38(7):799-802. doi: 10.1002/cbin.10262.
Elena G Starikova 1,  L A Tashireva,  V V Novitsky,  N V Ryazantseva
Affiliations

Affiliation

  • 1 Siberian State Medical University of the Ministry of Health Care of the Russian Federation, 634055, Tomsk, Russia.
PMID: 24677341 DOI: 10.1002/cbin.10262
Abstract

Mitochondrial permeabilisation after NO donor application did not activate caspase-9. We have studied the X-linked Apoptosis inhibitor (XIAP) and Aven protein content in NO-treated Jurkat cells. The level of both proteins increased in NO-treated cells. Thus the increase in XIAP and Aven content could be the cause of the lack of caspase-9 activity after mitochondrial permeabilisation in NO-treated Jurkat cells.

Keywords

Aven; XIAP; apoptosis; caspase; mitochondria; nitric oxide.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-126166
    98.50%, NO Donor