2. Academic Validation
  3. Sequestered fulvinol-related polyacetylenes in Peltodoris atromaculata

Sequestered fulvinol-related polyacetylenes in Peltodoris atromaculata

  • J Nat Prod. 2014 Jul 25;77(7):1678-84. doi: 10.1021/np500298h.
M Letizia Ciavatta 1,  Genoveffa Nuzzo,  Kentaro Takada,  Véronique Mathieu,  Robert Kiss,  Guido Villani,  Margherita Gavagnin
Affiliations

Affiliation

  • 1 Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB) , Via Campi Flegrei, 34, 80078 Pozzuoli, Naples, Italy.
PMID: 24950030 DOI: 10.1021/np500298h
Abstract

The Mediterranean dorid nudibranch Peltodoris atromaculata that had been collected while feeding on Haliclona fulva was shown to sequester long-chain fulvinol-like polyacetylene metabolites (compounds 2-5) from the prey. They were isolated along with previously reported bromorenierins from the diethyl ether extracts of both the mollusk and the Sponge. Their structures were elucidated by NMR spectroscopy and tandem FABMS analysis. Compound 5 exhibited in vitro growth inhibitory effects against the SKMEL-28 melanoma cell line.

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