2. Academic Validation
  3. Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

  • Bioorg Med Chem Lett. 2014 Sep 1;24(17):4095-8. doi: 10.1016/j.bmcl.2014.07.066.
Yehee Lee 1,  Weihong Wang 1,  Hiyoung Kim 1,  Awadut G Giri 1,  Dong Hwan Won 1,  Dongyup Hahn 1,  Kyung Ryul Baek 1,  Jihye Lee 1,  Inho Yang 1,  Hyukjae Choi 2,  Sang-Jip Nam 3,  Heonjoong Kang 4
Affiliations

Affiliations

  • 1 Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Republic of Korea.
  • 2 College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Republic of Korea.
  • 3 Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: sjnam@ewha.ac.kr.
  • 4 Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Republic of Korea; Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Republic of Korea. Electronic address: hjkang@snu.ac.kr.
PMID: 25124114 DOI: 10.1016/j.bmcl.2014.07.066
Abstract

Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine Sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas Cancer cells (IC50=11.4 μM).

Keywords

Cytotoxicity; Phorbaketals; Phorbas sp..

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