2. Academic Validation
  3. 6-Deoxy-13-hydroxy-8,11-dione-dihydrogranaticin B, an intermediate in granaticin biosynthesis, from Streptomyces sp. CPCC 200532

6-Deoxy-13-hydroxy-8,11-dione-dihydrogranaticin B, an intermediate in granaticin biosynthesis, from Streptomyces sp. CPCC 200532

  • J Nat Prod. 2014 Sep 26;77(9):2130-3. doi: 10.1021/np500138k.
Bingya Jiang 1,  Shufen Li,  Wei Zhao,  Ting Li,  Lijie Zuo,  Yanni Nan,  Linzhuan Wu,  Hongyu Liu,  Liyan Yu,  Guangzhi Shan,  Limin Zuo
Affiliations

Affiliation

  • 1 Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 25153802 DOI: 10.1021/np500138k
Abstract

A new granaticin analogue and its hydrolysis product were isolated from Streptomyces sp. CPCC 200532. Their structures were determined to be 6-deoxy-13-hydroxy-8,11-dione-dihydrogranaticins B (1) and A (2), respectively, by detailed analysis of spectroscopic data. Compound 1 was regarded as an intermediate in granaticin biosynthesis, as it was bioconvertable to granaticin B. Compared to granaticin B, 1 showed similar cytotoxicity against Cancer cell line HCT116, but decreased cytotoxicity against Cancer cell lines A549, HeLa, and HepG2. Compound 2 displayed lower cytotoxicity than 1 against all four Cancer cell lines tested.

Figures
Products