2. Academic Validation
  3. Neolignans, lignans and glycoside from the fruits of Melia toosendan

Neolignans, lignans and glycoside from the fruits of Melia toosendan

  • Fitoterapia. 2014 Dec:99:92-8. doi: 10.1016/j.fitote.2014.09.008.
Lun Wang 1,  Fu Li 2,  Chun-Yan Yang 1,  Ashfaq-Ahmad Khan 3,  Xin Liu 4,  Ming-Kui Wang 5
Affiliations

Affiliations

  • 1 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 2 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
  • 3 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; Phytopharmaceutical and Neutraceutical Research Laboratories, Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
  • 4 Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China.
  • 5 Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: wangmk@cib.ac.cn.
PMID: 25250895 DOI: 10.1016/j.fitote.2014.09.008
Abstract

Four new neolignans, meliasendanins A-D (1-4), and a new glycoside, toosenoside A (5), together with ten known ones (6-15), were isolated from a n-BuOH partition of the fruits of Melia toosendan. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously. Meliasendanin A (1) was a rare neolignan containing isochroman moiety, and its absolute configuration was determined using a CD spectrum. Toosenoside A (5) was an unusual glycoside with a rare naturally occurring aglycone and its structure was confirmed by X-ray single crystal diffraction analysis. The antioxidant activity of the isolated neolignans and Lignans was evaluated by ABTS radical-scavenging assay. Compounds 1 and 13 exhibited strong antioxidant activity, with IC₅₀ values of 62.8 and 45.1 μM, respectively.

Keywords

Antioxidant activity; Glycoside; Lignans; Melia toosendan; Meliaceae; Neolignans.

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