2. Academic Validation
  3. Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives

Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives

  • Bioorg Med Chem Lett. 2015 Jan 15;25(2):313-6. doi: 10.1016/j.bmcl.2014.11.042.
Daisuke Yamamuro 1,  Ryuji Uchida 1,  Masaki Ohtawa 1,  Shiho Arima 1,  Yushi Futamura 2,  Masumi Katane 1,  Hiroshi Homma 1,  Tohru Nagamitsu 1,  Hiroyuki Osada 2,  Hiroshi Tomoda 3
Affiliations

Affiliations

  • 1 Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
  • 2 RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
  • 3 Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Electronic address: tomodah@pharm.kitasato-u.ac.jp.
PMID: 25488842 DOI: 10.1016/j.bmcl.2014.11.042
Abstract

5-(4'-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from Fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.

Keywords

5-(4′-Methoxyphenyl)-oxazole; Caenorhabditis elegans; Hatch inhibition.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-114521
    Nematode Growth Inhibitor