2. Academic Validation
  3. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta

Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta

  • J Nat Prod. 2015 Mar 27;78(3):493-9. doi: 10.1021/np5009762.
Matthew J Bertin 1,  Sarah L Schwartz 2,  John Lee 1,  Anton Korobeynikov 3 4 5,  Pieter C Dorrestein 6,  Lena Gerwick 1,  William H Gerwick 1 6
Affiliations

Affiliations

  • 1 †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92037, United States.
  • 2 §Environmental Systems Program, University of California-San Diego, La Jolla, California 92093, United States.
  • 3 ∥Department of Statistical Modeling, St. Petersburg State University, St. Petersburg, Russia.
  • 4 ∇Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia.
  • 5 □The Center for Algorithmic Biotechnology, St. Petersburg State University, St. Petersburg, Russia.
  • 6 #Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, California 92093, United States.
PMID: 25668560 DOI: 10.1021/np5009762
Abstract

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean Sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated Microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

Figures
Products