2. Academic Validation
  3. Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

  • Bioorg Med Chem Lett. 2015 Mar 15;25(6):1192-5. doi: 10.1016/j.bmcl.2015.01.065.
Julia Heimberger 1,  Hannah C Cade 1,  Jihan Padgett 2,  Vinoth Sittaramane 2,  Abid Shaikh 3
Affiliations

Affiliations

  • 1 Department of Chemistry, Georgia Southern University, 521 College of Education Drive, Statesboro, GA 30460-8064, USA.
  • 2 Department of Biology, Georgia Southern University, 1332 Southern Drive, Statesboro, GA 30460-8042, USA.
  • 3 Department of Chemistry, Georgia Southern University, 521 College of Education Drive, Statesboro, GA 30460-8064, USA. Electronic address: malnu@georgiasouthern.edu.
PMID: 25690788 DOI: 10.1016/j.bmcl.2015.01.065
Abstract

Herbarin A and B were isolated from the Fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.

Keywords

Antioxidant properties; Natural products; Total synthesis; Toxicity; Zebrafish.

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