2. Academic Validation
  3. Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs)

Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs)

  • Bioorg Med Chem Lett. 2015 Apr 1;25(7):1412-6. doi: 10.1016/j.bmcl.2015.02.048.
Le Duc Dat 1,  Nguyen Phuong Thao 1,  Bui Huu Tai 1,  Bui Thi Thuy Luyen 2,  Sohyun Kim 3,  Jung Eun Koo 3,  Young Sang Koh 3,  Nguyen The Cuong 4,  Nguyen Van Thanh 5,  Nguyen Xuan Cuong 5,  Nguyen Hoai Nam 5,  Phan Van Kiem 5,  Chau Van Minh 6,  Young Ho Kim 7
Affiliations

Affiliations

  • 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghido, Caugiay, Hanoi, Vietnam; College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.
  • 2 College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.
  • 3 School of Medicine, Brain Korea 21 PLUS Program, and Institute of Medical Science, Jeju National University, Jeju 690-756, South Korea.
  • 4 Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Nghido, Caugiay, Hanoi, Vietnam.
  • 5 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghido, Caugiay, Hanoi, Vietnam.
  • 6 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghido, Caugiay, Hanoi, Vietnam. Electronic address: cvminh@vast.vn.
  • 7 College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea. Electronic address: yhk@cnu.ac.kr.
PMID: 25769817 DOI: 10.1016/j.bmcl.2015.02.048
Abstract

Chemical investigation of Kandelia candel resulted in the isolation of 19 compounds (1-19), including one new sesquiterpene glycoside, kandelside (1), three megastigman glycoside compounds (7-9), 16 known phenolic compounds (2-6 and 10-19). Structures of the isolated compounds were elucidated based on spectral data comparison with reported values. Isolated compounds were also evaluated for their inhibitory effects on the production of pro-inflammatory cytokines interleukin (IL)-12 p40, IL-6, and tumor necrosis factor α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among these compounds, compound 9 exhibited strong inhibitory activity against IL-6 production (IC50=0.07 ± 0.05 μM) and moderate inhibitory activity against TNF-α production (IC50=49.86 ± 1.02 μM), but exhibited no activity on IL-12 p40 production. Compounds 5 and 6 significantly inhibited IL-12 p40, IL-6, and TNF-α production with IC50 values of 11.68 ± 0.38, 44.52 ± 1.08, and 28.73 ± 0.96 μM, respectively.

Keywords

Anti-inflammatory activity; Kandelia candel; Kandelside; Rhizpphoraceae.

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