2. Academic Validation
  3. Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology

Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology

  • Pharmacol Res. 2015 Sep;99:11-5. doi: 10.1016/j.phrs.2015.05.001.
Pengli Zheng 1,  Qiao Wang 1,  Junlin Teng 1,  Jianguo Chen 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
  • 2 State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China; Center for Quantitative Biology, Peking University, Beijing 100871, China. Electronic address: chenjg@pku.edu.cn.
PMID: 25976680 DOI: 10.1016/j.phrs.2015.05.001
Abstract

Tumor metastasis is a key cause of Cancer mortality, and inhibiting migration of Cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as targets for pharmacological research of anti-metastatic drugs. This review briefly introduces the multi-function of these two proteins, and discusses the mechanism of how they regulate cell migration and tumor metastasis.

Keywords

Anti-metastasis; Calumenin; Cell migration; Fibulin-1.

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