2. Academic Validation
  3. Cardiotrophin-1: A multifaceted cytokine

Cardiotrophin-1: A multifaceted cytokine

  • Cytokine Growth Factor Rev. 2015 Oct;26(5):523-32. doi: 10.1016/j.cytogfr.2015.07.009.
Miguel López-Yoldi 1,  María J Moreno-Aliaga 2,  Matilde Bustos 3
Affiliations

Affiliations

  • 1 Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; Centre for Nutrition Research, University of Navarra, Pamplona, Spain.
  • 2 Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; Centre for Nutrition Research, University of Navarra, Pamplona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
  • 3 Area of Hepatology and Gene Therapy, CIMA (Center for Applied Medical Research) University of Navarra, Pamplona, Spain. Electronic address: mbustos@unav.es.
PMID: 26188636 DOI: 10.1016/j.cytogfr.2015.07.009
Abstract

Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines that have pleiotropic functions on different tissues and cell types. Although many effects of CT-1 have been described on the heart, there is an extensive research showing important protective effects in other organs such as liver, kidney or nervous system. Recently, several studies have pointed out that CT-1 might also play a key role in the regulation of body weight and intermediate metabolism. This paper will review many aspects of CT-1 physiological role in several organs and discuss data for consideration in therapeutic approaches.

Keywords

Cardiotrophin-1; Cytokines; Cytoprotection; IL-6; Metabolism.

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