2. Academic Validation
  3. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects

Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects

  • Neural Regen Res. 2015 Jul;10(7):1125-33. doi: 10.4103/1673-5374.160109.
Zhen Zhang 1,  Tao Sun 1,  Jian-Guo Niu 2,  Zhen-Quan He 2,  Yang Liu 3,  Feng Wang 1
Affiliations

Affiliations

  • 1 Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China ; Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
  • 2 Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
  • 3 Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
PMID: 26330838 DOI: 10.4103/1673-5374.160109
Abstract

Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in Epilepsy Models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and Apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.

Keywords

NSFC grant; apoptosis; brain inflammation; brain injury; epilepsy; inducible nitric oxide synthase; interleukin-1 beta; interleukin-6; nerve regeneration; neural regeneration; neuroprotection; nitric oxide; nuclear factor-κB; prostaglandin E2.

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