Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5597-600. doi: 10.1016/j.bmcl.2015.10.040.

Quoc Anh Ngo ¹, Le Anh Nguyen ², Ngoc Binh Vo ², Thuy Hang Nguyen ², Fanny Roussi ³, The Hung Nguyen ⁴, Van Tuyen Nguyen ²

Affiliations

1 Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam. Electronic address: ngoquocanh74m@yahoo.com.
2 Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam.
3 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, UPR 2301 du CNRS, Université Paris Sud, 1 avenue de la terrasse, 91198 Gif sur Yvette Cedex, France.
4 Ministry of Science and Technology, Viet Nam.

PMID: 26522953 DOI: 10.1016/j.bmcl.2015.10.040

Abstract

A new series of vinca-alkaloids derivatives containing various α,β-unsaturated aromatic side chains was synthesized. Four new vinca-alkaloids derivatives showed selective cytotoxicities against KB tumor cell lines with IC50 value below 0.1 μM, thus comparable with vinblastine.

Keywords

Cytotoxicity; Sarcodictyins; Tubulin; Vinca alkaloids.

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