2. Academic Validation
  3. Meroterpenoids from a Tropical Dysidea sp. Sponge

Meroterpenoids from a Tropical Dysidea sp. Sponge

  • J Nat Prod. 2015 Nov 25;78(11):2814-21. doi: 10.1021/acs.jnatprod.5b00867.
Chang-Kwon Kim 1,  Jung-Kyun Woo 1,  Seong-Hwan Kim 1,  Eunji Cho 2,  Yeon-Ju Lee 3,  Hyi-Seung Lee 3,  Chung J Sim 4,  Dong-Chan Oh 1,  Ki-Bong Oh 2,  Jongheon Shin 1
Affiliations

Affiliations

  • 1 Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
  • 2 Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-921, Korea.
  • 3 Marine Natural Products Laboratory, Korea Institute of Ocean Science & Technology , P.O. Box 29, Seoul 425-600, Korea.
  • 4 Department of Biological Science, College of Life Science and Nano Technology, Hannam University , 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea.
PMID: 26551342 DOI: 10.1021/acs.jnatprod.5b00867
Abstract

Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. Sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene Quinones containing taurine-derived substituents. Compounds 4-6 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na(+)/K(+)-ATPase.

Figures