2. Academic Validation
  3. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells

The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells

  • Org Biomol Chem. 2016 Jan 21;14(3):947-56. doi: 10.1039/c5ob02229k.
Mark C Bagley 1,  Jessica E Dwyer,  Mohammed Baashen,  Matthew C Dix,  Paola G S Murziani,  Michal J Rokicki,  David Kipling,  Terence Davis
Affiliations

Affiliation

  • 1 Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex, BN1 9QJ, UK. m.c.bagley@sussex.ac.uk.
PMID: 26611938 DOI: 10.1039/c5ob02229k
Abstract

Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK Inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-118612
    99.61%, p38 MAPK Inhibitor