RO3201195

Cat. No.: HY-118612 Purity: 99.77%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

RO3201195 (compound 1) is an inhibitor of p38 MAPK. RO3201195 inhibits WS cell proliferation with IC₅₀ value of 190 nM.

For research use only. We do not sell to patients.

RO3201195 Chemical Structure

CAS No. : 249937-52-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

Biological Activity
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References
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Description

RO3201195 (compound 1) is an inhibitor of p38 MAPK. RO3201195 inhibits WS cell proliferation with IC₅₀ value of 190 nM^[1].

Molecular Weight

371.36

Formula

C₁₉H₁₈FN₃O₄

CAS No.

249937-52-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(OCC(CO)O)=C1)C2=C(N(N=C2)C3=CC=C(C=C3)F)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (134.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6928 mL	13.4640 mL	26.9281 mL
5 mM	0.5386 mL	2.6928 mL	5.3856 mL
10 mM	0.2693 mL	1.3464 mL	2.6928 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (245 KB) HNMR (269 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Mark C. Bagley, et al. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells. Org Biomol Chem. 2016, 14, 3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6928 mL	13.4640 mL	26.9280 mL	67.3201 mL
	5 mM	0.5386 mL	2.6928 mL	5.3856 mL	13.4640 mL
	10 mM	0.2693 mL	1.3464 mL	2.6928 mL	6.7320 mL
	15 mM	0.1795 mL	0.8976 mL	1.7952 mL	4.4880 mL
	20 mM	0.1346 mL	0.6732 mL	1.3464 mL	3.3660 mL
	25 mM	0.1077 mL	0.5386 mL	1.0771 mL	2.6928 mL
	30 mM	0.0898 mL	0.4488 mL	0.8976 mL	2.2440 mL
	40 mM	0.0673 mL	0.3366 mL	0.6732 mL	1.6830 mL
	50 mM	0.0539 mL	0.2693 mL	0.5386 mL	1.3464 mL
	60 mM	0.0449 mL	0.2244 mL	0.4488 mL	1.1220 mL
	80 mM	0.0337 mL	0.1683 mL	0.3366 mL	0.8415 mL
	100 mM	0.0269 mL	0.1346 mL	0.2693 mL	0.6732 mL

RO3201195 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO3201195249937-52-8RO 3201195RO-3201195p38 MAPKcell proliferationWS cellsInhibitorinhibitorinhibit

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RO3201195

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