2. Academic Validation
  3. Trifluoperazine: A Sprightly Old Drug

Trifluoperazine: A Sprightly Old Drug

  • J Psychosoc Nurs Ment Health Serv. 2016 Jan;54(1):20-2. doi: 10.3928/02793695-20151223-01.
Robert H Howland
PMID: 26760133 DOI: 10.3928/02793695-20151223-01
Abstract

Trifluoperazine, developed in the mid-1950s and introduced in 1959 as an anxiolytic and antipsychotic agent, has been an extensively studied drug molecule that has been used as a Calmodulin inhibitor. Regulation of Calmodulin has important roles in cellular proliferation, inflammation, neurodegeneration, and other pathological processes. Trifluoperazine also inhibits P-glycoprotein, a protein that transports organic compounds across cell membranes and the blood-brain barrier. Trifluoperazine is currently approved for the treatment of schizophrenia as well as for the treatment of non-psychotic anxiety, but has other potential clinical uses based on Calmodulin and P-glycoprotein inhibition.

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