2. Academic Validation
  3. The CXCL8-CXCR1/2 pathways in cancer

The CXCL8-CXCR1/2 pathways in cancer

  • Cytokine Growth Factor Rev. 2016 Oct;31:61-71. doi: 10.1016/j.cytogfr.2016.08.002.
Qian Liu 1,  Anping Li 2,  Yijun Tian 1,  Jennifer D Wu 3,  Yu Liu 4,  Tengfei Li 2,  Yuan Chen 1,  Xinwei Han 5,  Kongming Wu 6
Affiliations

Affiliations

  • 1 Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 2 Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • 3 Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.
  • 4 Department of Geriatric, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 5 Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Electronic address: hanxinwei2006@163.com.
  • 6 Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: kmwu@tjh.tjmu.edu.cn.
PMID: 27578214 DOI: 10.1016/j.cytogfr.2016.08.002
Abstract

Persistent Infection or chronic inflammation contributes significantly to tumourigenesis and tumour progression. C-X-C motif ligand 8 (CXCL8) is a chemokine that acts as an important multifunctional cytokine to modulate tumour proliferation, invasion and migration in an autocrine or paracrine manner. Studies have suggested that CXCL8 and its cognate receptors, C-X-C Chemokine Receptor 1 (CXCR1) and C-X-C Chemokine Receptor 2 (CXCR2), mediate the initiation and development of various cancers including breast Cancer, prostate Cancer, lung Cancer, colorectal carcinoma and melanoma. CXCL8 also integrates with multiple intracellular signalling pathways to produce coordinated effects. Neovascularisation, which provides a basis for fostering tumour growth and metastasis, is now recognised as a critical function of CXCL8 in the tumour microenvironment. In this review, we summarize the biological functions and clinical significance of the CXCL8 signalling axis in Cancer. We also propose that CXCL8 may be a potential therapeutic target for Cancer treatment.

Keywords

Angiogenesis; CXCL8; CXCR1; CXCR2; Cancer; Metastasis.

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