2. Academic Validation
  3. Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes

Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes

  • Biofouling. 2017 Feb;33(2):156-168. doi: 10.1080/08927014.2017.1280732.
Anabela Borges 1 2 3,  Pedro Sousa 1,  Alexandra Gaspar 2,  Santiago Vilar 4 5,  Fernanda Borges 2,  Manuel Simões 1
Affiliations

Affiliations

  • 1 a LEPABE, Department of Chemical Engineering, Faculty of Engineering , University of Porto , Porto , Portugal.
  • 2 b CIQ-UP, Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , Porto , Portugal.
  • 3 c CECAV-Veterinary and Animal Science Research Center, Department of Veterinary Science , University of Trás-os-Montes e Alto Douro , Vila Real , Portugal.
  • 4 d Department of Biomedical Informatics , Columbia University , New York , USA.
  • 5 e Department of Organic Chemistry, Faculty of Pharmacy , University of Santiago de Compostela , Santiago de Compostela , Spain.
PMID: 28140677 DOI: 10.1080/08927014.2017.1280732
Abstract

Disruption of cell-cell communication or quorum sensing (QS) is considered a stimulating approach for reducing Bacterial pathogenicity and resistance. Although several QS inhibitors (QSIs) have been discovered so far their clinical use remains distant. This problem can be circumvented by searching for QSI among drugs already approved for the treatment of different diseases. In this context, Antibiotics have earned special attention. Whereas at high concentrations Antibiotics exert a killing effect, at lower concentrations they may act as signaling molecules and as such can modulate gene expression. In this study, the Antibiotic furvina was shown to be able to cause inhibition of the 3-oxo-C12-HSL-dependent QS system of Pseudomonas aeruginosa. Furvina interacts with the LasI/LasR system. The data were validated by modeling studies. Furvina can also reduce biofilm formation and decrease the production of QS-controlled virulence factors.

Keywords

Antimicrobial resistance; antivirulence; biofilm; furvina; quorum sensing inhibition.

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