1. Academic Validation
  2. Structures of fibrostatins, new inhibitors of prolyl hydroxylase

Structures of fibrostatins, new inhibitors of prolyl hydroxylase

  • J Antibiot (Tokyo). 1987 Sep;40(9):1239-48. doi: 10.7164/antibiotics.40.1239.
K Ohta 1 F Kasahara T Ishimaru Y Wada T Kanamaru H Okazaki
Affiliations

Affiliation

  • 1 Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
Abstract

The structures of six inhibitors of prolyl hydroxylase, fibrostatins A, B, C, D, E and F produced by a strain of Streptomyces, were deduced to be 1, 2, 3, 4, 5 and 6, respectively, from chemical and spectroscopic evidence, especially from extensive 13C NMR studies including selective decoupling and low power selective decoupling experiments monitored by 13C-1H long-range couplings. These compounds are the first naturally occurring 2,6,7- or 3,6,7-tri-substituted or 2,3,6,7-tetra-substituted 5-hydroxy-1,4-naphthoquinone inhibitors possessing N-acetyl-L-cystein-S-yl moieties in the molecule.

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