2. Academic Validation
  3. Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity

Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity

  • Bioorg Med Chem Lett. 2017 Apr 1;27(7):1525-1529. doi: 10.1016/j.bmcl.2017.02.040.
Phan Van Kiem 1,  Le Thi Huyen 2,  Dan Thuy Hang 3,  Nguyen Xuan Nhiem 3,  Bui Huu Tai 3,  Hoang Le Tuan Anh 3,  Pham Van Cuong 3,  Tran Hong Quang 3,  Chau Van Minh 3,  Nguyen Van Dau 2,  Young-A Kim 4,  Lalita Subedi 5,  Sun Yeou Kim 5,  Seung Hyun Kim 6
Affiliations

Affiliations

  • 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: phankiem@yahoo.com.
  • 2 Faculty of Chemistry, VNU University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam.
  • 3 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 4 Korea Institute of Ocean Science & Technology, Ansan 15627, Republic of Korea.
  • 5 College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
  • 6 College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 21983, Republic of Korea. Electronic address: kimsh11@yonsei.ac.kr.
PMID: 28262525 DOI: 10.1016/j.bmcl.2017.02.040
Abstract

Using various chromatographic methods, five new sesquiterpene derivatives named smenohaimiens A-E (1-5) and five known, 19-hydroxy-polyfibrospongol B (6), ilimaquinone (7), dictyoceratin C (8), polyfibrospongol A (9), and polyfibrospongol B (10) were isolated from the marine Sponge Smenospongia cerebriformis Duchassaing & Michelotti, 1864. Their structures were assigned by 1D, 2D NMR spectroscopic analysis, HR ESI MS, and calculations of the electron circular dichroism spectra. All compounds were evaluated for the inhibitory activity against NO production in lipopolysaccharide-stimulated in BV2 microglia cells. As the results, compound 7 significantly inhibited NO production with the IC50 value of 10.40±1.28µM. The remaining compounds showed moderate inhibitory NO production activities with IC50 values ranging from 24.37 to 30.43µM.

Keywords

Anti-inflammation; Sesquiterpene derivative; Smenohaimiens A–E; Smenospongia cerebriformis.

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