2. Academic Validation
  3. Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper

Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper

  • J Nat Prod. 2017 May 26;80(5):1436-1445. doi: 10.1021/acs.jnatprod.6b01105.
Jing Li 1 2,  Bin-Bin Gu 1,  Fan Sun 1,  Jian-Rong Xu 3,  Wei-Hua Jiao 1,  Hao-Bing Yu 1,  Bing-Nan Han 1,  Fan Yang 1,  Xi-Chun Zhang 4,  Hou-Wen Lin 1
Affiliations

Affiliations

  • 1 Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
  • 2 College of Pharmacy, Jinan University , Guangzhou 510632, China.
  • 3 Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine , Shanghai 20025, China.
  • 4 Institute of Pharmaceutical & Food Engineering, Shanxi University of Traditional Chinese Medicine , Taiyuan 030024, China.
PMID: 28398051 DOI: 10.1021/acs.jnatprod.6b01105
Abstract

Nine new sesquiterpene Quinones/hydroquinones (1-7, 10, and 12), three solvent-generated artifacts (8, 9, and 11), and three known compounds, 5-epi-smenospongine (13), smenospongine (14), and smenospongiadine (15), were isolated from the marine Sponge Spongia pertusa Esper. The planar structures of the new compounds were elucidated on the basis of spectroscopic analyses. Their absolute configurations were determined by comparison between the calculated and experimental ECD spectra. In the cytotoxicity bioassay, compounds 13-15 exhibited activities against the human Cancer cell lines U937, HeLa, and HepG2, with most potent cytotoxicities to U937 cells with IC50 values of 2.8, 1.5, and 0.6 μM, respectively. In addition, compound 6 displayed CDK-2 affinity with a Kd value of 4.8 μM in a surface plasmon resonance assay.

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