2. Academic Validation
  3. Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis

Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis

  • J Nat Prod. 2017 Jul 28;80(7):2060-2066. doi: 10.1021/acs.jnatprod.7b00255.
Tsegaye Deyou 1 2,  Makungu Marco 1,  Matthias Heydenreich 3,  Fangfang Pan 4 5,  Amra Gruhonjic 2 6,  Paul A Fitzpatrick 6,  Andreas Koch 3,  Solomon Derese 1,  Jerry Pelletier 7,  Kari Rissanen 4,  Abiy Yenesew 1,  Máté Erdélyi 2 8
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
  • 2 Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.
  • 3 Institut für Chemie, Universität Potsdam , Karl-Liebknecht-Straße 24-25, D-14476, Potsdam, Germany.
  • 4 Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box 35, FI-40014, Jyvaskyla, Finland.
  • 5 College of Chemistry, Central China Normal University , Wuhan, 430079, People's Republic of China.
  • 6 Sahlgrenska Cancer Centre, University of Gothenburg , SE-405 30 Gothenburg, Sweden.
  • 7 Department of Biochemistry, McGill University , Montreal, QC H3G 1Y6, Canada.
  • 8 Swedish NMR Center, University of Gothenburg , P.O. Box 465, SE-405 30, Gothenburg, Sweden.
PMID: 28665590 DOI: 10.1021/acs.jnatprod.7b00255
Abstract

A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast Cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 μM, respectively.

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