2. Academic Validation
  3. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity

  • Brain Res. 1986 Sep 10;382(1):169-73. doi: 10.1016/0006-8993(86)90127-7.
J Davies,  R H Evans,  P L Herrling,  A W Jones,  H J Olverman,  P Pook,  J C Watkins
PMID: 2876749 DOI: 10.1016/0006-8993(86)90127-7
Abstract

Properties of a new potent antagonist acting selectively at N-methyl-D-aspartate (NMDA) type excitatory amino acid receptors are described. This compound, 3-((+/-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) is more potent than all previously reported NMDA antagonists in depressing mammalian spinal neuronal responses (cat and immature rat), in its affinity for [3H]D-AP5 (a radiolabelled NMDA antagonist) binding sites on rat brain membranes, and as an anticonvulsant in mice.

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