2. Academic Validation
  3. Total Synthesis of (+)-Medicarpin

Total Synthesis of (+)-Medicarpin

  • J Nat Prod. 2017 Dec 22;80(12):3284-3288. doi: 10.1021/acs.jnatprod.7b00741.
Xiaoming Yang 1,  Yu Zhao 1,  Min-Tsang Hsieh 1 2 3,  Guang Xin 1,  Rong-Tsun Wu 4,  Pei-Lun Hsu 4,  Lin-Yea Horng 4,  Hui-Ching Sung 4,  Chien-Hsin Cheng 5,  Kuo-Hsiung Lee 1 2
Affiliations

Affiliations

  • 1 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
  • 2 Chinese Medicine Research and Development Center, China Medical University and Hospital , Taichung 40402, Taiwan.
  • 3 School of Pharmacy, China Medical University , Taichung 404, Taiwan.
  • 4 Research Center for Drug Discovery, National Yang-Ming University , Taipei 112, Taiwan.
  • 5 PhytoHealth Corporation, Maywafa Biopharma Group, Taipei 105, Taiwan.
PMID: 29164880 DOI: 10.1021/acs.jnatprod.7b00741
Abstract

(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral Oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as an erythropoietin inducer for erythropoietin-deficient diseases.

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