2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. (+)-Medicarpin

(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action.

For research use only. We do not sell to patients.

(+)-Medicarpin Chemical Structure

(+)-Medicarpin Chemical Structure

CAS No. : 33983-39-0

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Based on 1 publication(s) in Google Scholar

Other Forms of (+)-Medicarpin:

(+)-Medicarpin Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

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Description

(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action[1].

IC50 & Target[1]

ERβ

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
39.5 μM
Compound: 32
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 18440233]
B16-BL6 IC50
42.4 μM
Compound: 32
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 18440233]
HeLa IC50
23.4 μM
Compound: 32
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 18440233]
HT-1080 IC50
28.4 μM
Compound: 32
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 18440233]
Lewis lung carcinoma cell line IC50
17.2 μM
Compound: 32
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
[PMID: 18440233]
Molecular Weight

270.28

Formula

C16H14O4
CAS No.
SMILES

OC1=CC=C([C@]2([H])[C@](C3=CC=C(OC)C=C3O2)([H])CO4)C4=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(+)-Medicarpin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Medicarpin33983-39-0Estrogen Receptor/ERRInhibitorinhibitorinhibit

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