2. Academic Validation
  3. trans-Double Bond-Containing Liposomes as Potential Carriers for Drug Delivery

trans-Double Bond-Containing Liposomes as Potential Carriers for Drug Delivery

  • Molecules. 2017 Nov 28;22(12):2082. doi: 10.3390/molecules22122082.
Giorgia Giacometti 1 2,  Marina Marini 3,  Kyriakos Papadopoulos 4,  Carla Ferreri 5,  Chryssostomos Chatgilialoglu 6 7
Affiliations

Affiliations

  • 1 Institute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi, Athens, Greece. g.giacometti@inn.demokritos.gr.
  • 2 Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Via Belmeloro 8, 40126 Bologna, Italy. g.giacometti@inn.demokritos.gr.
  • 3 Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Via Belmeloro 8, 40126 Bologna, Italy. marina.marini@unibo.it.
  • 4 Institute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi, Athens, Greece. k.papadopoulos@inn.demokritos.gr.
  • 5 ISOF, Consiglio Nazionale Delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy. carla.ferreri@isof.cnr.it.
  • 6 Institute of Nanoscience and Nanotechnology, N.C.S.R. "Demokritos", 15310 Agia Paraskevi, Athens, Greece. chrys@isof.cnr.it.
  • 7 ISOF, Consiglio Nazionale Delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy. chrys@isof.cnr.it.
PMID: 29182583 DOI: 10.3390/molecules22122082
Abstract

The use of liposomes has been crucial for investigations in biomimetic chemical biology as a membrane model and in medicinal chemistry for Drug Delivery. Liposomes are made of Phospholipids whose biophysical characteristics strongly depend on the type of fatty acid moiety, where natural unsaturated lipids always have the double bond geometry in the cis configuration. The influence of lipid double bond configuration had not been considered so far with respect to the competence of liposomes in delivery. We were interested in evaluating possible changes in the molecular properties induced by the conversion of the double bond from cis to trans geometry. Here we report on the effects of the addition of trans-phospholipids supplied in different amounts to other Liposome constituents (Cholesterol, neutral Phospholipids and cationic Surfactants), on the size, ζ-potential and stability of liposomal formulations and on their ability to encapsulate two dyes such as rhodamine B and fluorescein. From a biotechnological point of view, trans-containing liposomes proved to have different characteristics from those containing the cis analogues, and to influence the incorporation and release of the dyes. These results open new perspectives in the use of the unnatural lipid geometry, for the purpose of changing Liposome behavior and/or of obtaining molecular interferences, also in view of synergic effects of cell toxicity, especially in antitumoral strategies.

Keywords

cis-trans isomerization; drug-delivery system; liposomes; trans fatty acids; trans-phospholipids.

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