Chemogenetic control of gene expression and cell signaling with antiviral drugs

Nat Methods. 2018 Jul;15(7):519-522. doi: 10.1038/s41592-018-0042-y.

Elliot P Tague ¹, Hannah L Dotson ¹, Shannon N Tunney ¹, D Christopher Sloas ¹, John T Ngo ²

Affiliations

1 Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, USA.
2 Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, USA. jtngo@bu.edu.

PMID: 29967495 DOI: 10.1038/s41592-018-0042-y

Abstract

We developed a method in which the NS3 cis-protease from hepatitis C virus can be used as a ligand-inducible connection to control the function and localization of engineered proteins in mammalian cells. To demonstrate the versatility of this approach, we designed drug-sensitive transcription factors and transmembrane signaling proteins, the activities of which can be tightly and reversibly controlled through the use of clinically tested antiviral Protease Inhibitors.

Products

Cat. No.

Product Name

Description

Target

Research Area
HY-14434

Asunaprevir

99.84%, HCV Protease Inhibitor

HCV; HCV Protease; SARS-CoV

Infection
HY-15298

Grazoprevir

99.99%, HCV Protease Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-10241

Simeprevir

99.90%, HCV NS3/4A Inhibitor

HCV; HCV Protease; SARS-CoV; DNA/RNA Synthesis

Infection
HY-10238

Danoprevir

99.69%, HCV NS3/4A Inhibitor

HCV Protease; HCV; SARS-CoV

Infection
HY-10237

Boceprevir

98.79%, HCV NS3 Protease Inhibitor

HCV Protease; HCV; SARS-CoV

Infection

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