2. Academic Validation
  3. Bioactive Phenolic Components from the Twigs of Atalantia buxifolia

Bioactive Phenolic Components from the Twigs of Atalantia buxifolia

  • J Nat Prod. 2018 Jul 27;81(7):1534-1539. doi: 10.1021/acs.jnatprod.7b00938.
Fang-Rong Chang 1,  Pei-Shian Li,  Rosa Huang Liu 2,  Hao-Chun Hu,  Tsong-Long Hwang 3,  Jin-Ching Lee,  Shu-Li Chen,  Yang-Chang Wu 4,  Yuan-Bin Cheng 4
Affiliations

Affiliations

  • 1 National Research Institute of Chinese Medicine , Taipei 112 , Taiwan.
  • 2 School of Nutrition, College of Health Care and Management , Chung Shan Medical University , Taichung 402 , Taiwan.
  • 3 Graduate Institute of Natural Products, College of Medicine , Chang Gung University , Taoyuan 333 , Taiwan.
  • 4 Department of Medical Research , Kaohsiung Medical University Hospital , Kaohsiung 807 , Taiwan.
PMID: 29975532 DOI: 10.1021/acs.jnatprod.7b00938
Abstract

Five new compounds named buxifoximes A-C (1-3), buxifobenzoate (4), and 7- O-(7'-peroxygeranyl) coumarin (5), together with 25 known compounds, were identified from the twigs of Atalantia buxifolia. Compounds 1-3 are unique secondary metabolites with the aldoxime functionality. The structures of the isolates were determined on the basis of spectroscopic data analyses, and the structure of 1 was confirmed by an X-ray single-crystallographic analysis. With respect to bioactivity, antidengue virus, anti-inflammatory, and cytotoxic activities of all purified compounds were tested and evaluated. Compound 1 showed a significant anti-inflammatory effect by inhibiting superoxide anion generation with an IC50 value of 4.8 ± 0.7 μM. Among the Acridone Alkaloids, 5-hydroxy- N-methylseverifoline (23) exhibited antidengue activity (IC50 = 5.3 ± 0.4 μM), and atalaphyllinine (20) demonstrated cytotoxicity (IC50 = 6.5 ± 0.0 μM) against the human liver Cancer cell line, HepG2.

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