2. Academic Validation
  3. Deltamethrin toxicity: A review of oxidative stress and metabolism

Deltamethrin toxicity: A review of oxidative stress and metabolism

  • Environ Res. 2019 Mar:170:260-281. doi: 10.1016/j.envres.2018.12.045.
Qirong Lu 1,  Yaqi Sun 1,  Irma Ares 2,  Arturo Anadón 3,  Marta Martínez 2,  María-Rosa Martínez-Larrañaga 2,  Zonghui Yuan 1,  Xu Wang 4,  María-Aránzazu Martínez 2
Affiliations

Affiliations

  • 1 National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
  • 2 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain.
  • 3 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain. Electronic address: aanadon@ucm.es.
  • 4 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address: wangxu@mail.hzau.edu.cn.
PMID: 30599291 DOI: 10.1016/j.envres.2018.12.045
Abstract

Deltamethrin is widely used worldwide due to its valuable insecticidal activity against pests and parasites. Increasing evidence has shown that deltamethrin causes varying degrees of toxicity. Moreover, oxidative stress and metabolism are highly correlated with toxicity. For the first time, this review systematically summarizes the deltamethrin toxicity mechanism from the perspective of oxidative stress, including deltamethrin-mediated oxidative damage, antioxidant status, oxidative signaling pathways and modulatory effects of antagonists, synergists and placebos on oxidative stress. Further, deltamethrin metabolism, including metabolites, metabolic enzymes and pathways and deltamethrin metabolite toxicity are discussed. This review will shed new LIGHT on deltamethrin toxicity mechanisms and provide effective strategies to ensure pest control and prevention of human and animal poisoning.

Keywords

Deltamethrin; Metabolism; Oxidative stress; Signaling pathway; Toxicity.

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