2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Calcium Channel Caspase Apoptosis Bcl-2 Family NF-κB Interleukin Related
  4. Deltamethrin

Deltamethrin  (Synonyms: Decamethrin)

Cat. No.: HY-B1971 Purity: 99.93%
SDS COA Handling Instructions

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Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.

For research use only. We do not sell to patients.

Deltamethrin Chemical Structure

Deltamethrin Chemical Structure

CAS No. : 52918-63-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
100 mg USD 50 In-stock
250 mg USD 80 In-stock
500 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Deltamethrin:

Deltamethrin Related Antibodies

Top Publications Citing Use of Products

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control[1][2][3][4][5][6].

IC50 & Target

Caspase 3

 

Bcl-2

 

Bax

 

IL-1β

 

In Vitro

Deltamethrin (5-60 μM, 24 h) increases cytosolic free Ca2+ concentration and induces apoptosis in a concentration-dependent manner in OC2 human oral cancer cells[2].
Deltamethrin (0.5-100 μM, 24 h) inhibits thymocytes viability[3].
Deltamethrin (10-50 μM, 1-6 h) shows a concentration- and time-dependent enhancement in caspase-3 activity in murine thymocytes[3].
Deltamethrin (10-50 μM, 18 h) induces apoptosis in thymocytes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deltamethrin Related Antibodies

Cell Viability Assay[3]

Cell Line: Murine thymocytes
Concentration: 0.5 μM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM
Incubation Time: 6 h, 18 h
Result: Caused 32% and 59% loss in cell viability at 25 μM and 100 μM at 6 h.
Caused 46% and 68% loss in cell viability at 25 μM and 100 μM at 18 h.

Cell Cycle Analysis[3]

Cell Line: Murine thymocytes
Concentration: 10 μM, 25 μM, 50 μM
Incubation Time: 18 h
Result: Increased the number of apoptotic cells in a concentration-dependent manner.
In Vivo

Deltamethrin (5.6-18 mg/kg, Oral, once a day for 15 days) induces oxidative stress in mice[4].
Deltamethrin (60 mg/kg, Intraperitoneal injection, single dose) can increase the activity of Choline acetyltransferase (ChAT) in the striatum in rats[5].
Deltamethrin (15-45 mg/kg, Gavage, once a day for 12 weeks) promotes cardiomyocyte inflammation and apoptosis through inhibiting the Nrf2/HO-1 signaling pathway in quails[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino male mice[4]
Dosage: 5.6 mg/kg, 18 mg/kg
Administration: Oral
Result: Significantly induced lipid peroxidation (LPO) in liver and kidney.
Suppressed the activities of vital antioxidant enzymes such as glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT).
Decreased the glutathione (GSH) level.
Animal Model: Male Sprague-Dawley rats[5]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Modulated the hippocampal high-affinity choline uptake (HACU).
Increased the activity of ChAT in the hippocampus and cortex.
Increased the activity of striatal ChAT.
Clinical Trial
Molecular Weight

505.20

Formula

C22H19Br2NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1C(C)(C)[C@H]1/C=C(Br)\Br)O[C@H](C#N)C2=CC=CC(OC3=CC=CC=C3)=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (197.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9794 mL 9.8971 mL 19.7941 mL
5 mM 0.3959 mL 1.9794 mL 3.9588 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (4.95 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (4.95 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.93%

SDS (623 KB)

COA (253 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9794 mL 9.8971 mL 19.7941 mL 49.4854 mL
5 mM 0.3959 mL 1.9794 mL 3.9588 mL 9.8971 mL
10 mM 0.1979 mL 0.9897 mL 1.9794 mL 4.9485 mL
15 mM 0.1320 mL 0.6598 mL 1.3196 mL 3.2990 mL
20 mM 0.0990 mL 0.4949 mL 0.9897 mL 2.4743 mL
25 mM 0.0792 mL 0.3959 mL 0.7918 mL 1.9794 mL
30 mM 0.0660 mL 0.3299 mL 0.6598 mL 1.6495 mL
40 mM 0.0495 mL 0.2474 mL 0.4949 mL 1.2371 mL
50 mM 0.0396 mL 0.1979 mL 0.3959 mL 0.9897 mL
60 mM 0.0330 mL 0.1650 mL 0.3299 mL 0.8248 mL
80 mM 0.0247 mL 0.1237 mL 0.2474 mL 0.6186 mL
100 mM 0.0198 mL 0.0990 mL 0.1979 mL 0.4949 mL
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Deltamethrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deltamethrin52918-63-5DecamethrinEndogenous MetaboliteCalcium ChannelCaspaseApoptosisBcl-2 FamilyNF-κBInterleukin RelatedCa2+ channelsCa channelsNuclear factor-κBNuclear factor-kappaBILOC2 human oral cancer cellmurine thymocytepyrethroid insecticideInhibitorinhibitorinhibit

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