2. Academic Validation
  3. Circadian gene PER1 senses progesterone signal during human endometrial decidualization

Circadian gene PER1 senses progesterone signal during human endometrial decidualization

  • J Endocrinol. 2019 Sep 1;JOE-19-0284.R2. doi: 10.1530/JOE-19-0284.
Ying Zhang 1,  Nan Meng 2,  Haili Bao 3,  Yufei Jiang 4,  Ningjie Yang 5,  Kejia Wu 6,  Jinxiang Wu 7,  Haibin Wang 8,  Shuangbo Kong 9,  Yuanzhen Zhang 1
Affiliations

Affiliations

  • 1 Y Zhang, Department of Obstetrics and Gynecology, Wuhan University Zhongnan Hospital, Wuhan, China.
  • 2 N Meng, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
  • 3 H Bao, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
  • 4 Y Jiang, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
  • 5 N Yang, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
  • 6 K Wu, Department of Obstetrics and Gynecology, Wuhan University Zhongnan Hospital, Wuhan, China.
  • 7 J Wu, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
  • 8 H Wang, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
  • 9 S Kong, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
PMID: 31518992 DOI: 10.1530/JOE-19-0284
Abstract

Progesterone is an important hormone for female reproduction, however, how the fluctuation of progesterone acts upon reproductive processes remains largely unknown. Mounting evidence indicates a pivotal role of the circadian clock in sensing hormone dynamics for homeostatic regulation of physiological functions. Therefore, we sought to determine whether clock genes respond to progesterone signaling in female reproductive system. In this study, we tested the hypothesis that the circadian system could respond to progesterone signaling during human endometrial decidual transformation. The expression of the circadian gene PER1 increased immediately and remained elevated during human endometrial decidualization. The Progesterone Receptor activated PER1 transcription by directly binding to its promoter from the onset of the stromal proliferation-differentiation transition. PER1 knockout significantly downregulated the expression of some PGR target genes, and attenuated human endometrial decidual transformation by expediting FOXO1 protein degradation. In conclusion, progesterone could control the female reproductive process through sustained feedback from the circadian gene PER1, which is probably involved to P4-PR signaling responsiveness in the initiation and maintenance of decidualization.

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