1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

(PDE)

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12318
    IBMX
    Inhibitor 99.99%
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.
    IBMX
  • HY-B0764
    Bucladesine sodium
    Inhibitor 99.48%
    Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing.
    Bucladesine sodium
  • HY-16900
    Rolipram
    Inhibitor 99.45%
    Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
    Rolipram
  • HY-15455
    Roflumilast
    Inhibitor 99.98%
    Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
    Roflumilast
  • HY-153192
    Nerandomilast
    Inhibitor 99.93%
    Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).
    Nerandomilast
  • HY-W044525
    Phyllodulcin
    Inhibitor 98.15%
    Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling.
    Phyllodulcin
  • HY-169402
    PDE1-IN-9
    Inhibitor 98.74%
    PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes.
    PDE1-IN-9
  • HY-W003486
    5,7-Dichloropyrazolo[1,5-a]pyrimidine
    Inhibitor 99.16%
    5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is a pyrazolopyrimidine phosphodiesterase 10A (PDE10A) inhibitor (Ki=24 μM). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used in the study of schizophrenia.
    5,7-Dichloropyrazolo[1,5-a]pyrimidine
  • HY-15025
    Sildenafil
    Inhibitor 99.90%
    Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
    Sildenafil
  • HY-N0014
    Icariin
    Inhibitor 99.06%
    Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.
    Icariin
  • HY-12085
    Apremilast
    Inhibitor 99.91%
    Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.
    Apremilast
  • HY-14252
    Milrinone
    Inhibitor 99.80%
    Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.
    Milrinone
  • HY-B0809
    Theophylline
    Inhibitor 99.94%
    Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
    Theophylline
  • HY-B0312
    Dipyridamole
    Inhibitor 99.00%
    Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis.
    Dipyridamole
  • HY-100927
    Ro 20-1724
    Inhibitor 99.34%
    Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect.
    Ro 20-1724
  • HY-100912
    W-7 hydrochloride
    Inhibitor 99.96%
    W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor activity.
    W-7 hydrochloride
  • HY-17464
    Cilostazol
    Inhibitor 99.87%
    Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM.
    Cilostazol
  • HY-101772
    Ziritaxestat
    Inhibitor 99.93%
    Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and a Ki of 15 nM.
    Ziritaxestat
  • HY-117571
    Zatolmilast
    Inhibitor 99.50%
    Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
    Zatolmilast
  • HY-12501A
    ITI-214
    Inhibitor 99.19%
    ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions.
    ITI-214
Cat. No. Product Name / Synonyms Application Reactivity

PDE1

PDE2

PDE3

PDE4

PDE5

PDE6

PDE7

PDE9

PDE10

PDE11

PDE12

PDE8

Autotaxin

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Phosphodiesterase (PDE) Inhibitors, Antagonists, Activators & Modulators
Product NamePDE1PDE2PDE3PDE4PDE5PDE6PDE7PDE9PDE10PDE11PDE12PDE8AutotaxinPurity    
IBMX  
PDE3
PDE4
         99.99%
Rolipram   
PDE4
         99.45%
Roflumilast   
PDE4
         99.98%
PDE1-IN-9
PDE1C, IC50: 11 nM
            98.74%
Sildenafil    
PDE5
        99.90%
Icariin   
PDE4, IC50: 73.5 μM
PDE5, IC50: 432 nM
        99.06%
Apremilast   
PDE4, IC50: 74 nM
         99.91%
Milrinone  
PDE3
          99.80%
Theophylline  
PDE3
          99.94%
Ro 20-1724   
PDE4, Ki: 1930 nM
         99.34%
Ziritaxestat            
Autotaxin, IC50: 131 nM
Autotaxin, Ki: 15 nM
99.93%
Zatolmilast   
PDE4D3, IC50: 7.4 nM
PDE4D7, IC50: 7.8 nM
         99.50%
ITI-214
PDE1, Ki: 58 pM
PDE1A, Ki: 33 pM
PDE1B, Ki: 380 pM
PDE1C, Ki: 35 pM
            99.19%
Sildenafil citrate    
PDE5
        99.86%
Tadalafil    
PDE5
        99.92%
Crisaborole   
PDE4
         99.92%
EHNA hydrochloride 
hPDE2A, IC50: 0.8 μM
           99.61%
Bay 60-7550 
PDE2
           98.24%
PF-8380            
Autotaxin, IC50: 2.8 nM (In isolated enzyme assay)
99.05%
Butein   
PDE4, IC50: 10.4 μM
         99.95%
Cilostamide  
PDE3
          99.64%
Avanafil
PDE1, IC50: 53000 nM
PDE2, IC50: 51000 nM
 
PDE4, IC50: 5700 nM
PDE5, IC50: 5.2 nM
PDE6, IC50: 630 nM
PDE7, IC50: 27000 nM
 
PDE10, IC50: 6200 nM
    98.66%
Zaprinast    
PDE5
        99.95%
FPFT-2216     
PDE6D
       99.75%
Difamilast   
PDE4B, IC50: 11.2 nM
         99.63%
Ensifentrine  
PDE3, IC50: 0.4 nM
PDE4, IC50: 1479 nM
         99.70%
Moracin M   
PDE4D2, IC50: 2.9 μM
PDE4B2, IC50: 4.5 μM
PDE5A1, IC50: >40 μM
  
PDE9A2, IC50: >100 μM
     98.90%
HA130            
Autotaxin, IC50: 28 nM
99.46%
BRL-50481      
PDE7
      99.85%
D159687   
PDE4
         98.34%
MR-L2   
PDE4
         99.23%
Mardepodect        
PDE10
    99.04%
Balipodect        
PDE10
    99.47%
Mirodenafil dihydrochloride    
PDE5
        99.85%
Vardenafil
PDE1, IC50: 180 nM
 
PDE3, IC50: >1000 nM
PDE4, IC50: >1000 nM
PDE5, IC50: 0.7 nM
PDE6, IC50: 11 nM
       99.81%
Edelinontrine       
PDE9
     99.85%
PF-05180999 
PDE2A, IC50: 1.6 nM
    
PDE7B, IC50: 50.09 μM
 
PDE10A1, IC50: 2.03 μM
PDE11A4, IC50: 26.969 μM
   99.97%
DNMDP  
PDE3
          98.95%
BC11-38        
PDE10, IC50: >100 μM
PDE11, IC50: 0.28 μM
   99.42%
(S)-(+)-Rolipram   
PDE4, IC50: 1100 nM
         99.77%
MK-8189        
PDE10A, Ki: 29 pM
    99.88%
Cilomilast   
LPDE4, IC50: ~100 nM
HPDE4, IC50: 120 nM
         99.91%
GSK256066   
PDE4, IC50: 3.2 pM
         98.15%
BAY 2666605  
PDE3A, IC50: 87 nM
PDE3B, IC50: 50 nM
          99.74%
BI-2545            
Autotaxin
98.85%
TMX-4100     
PDE6D
       98.18%
Piclamilast
PDE1, IC50: >100 μM
PDE2, IC50: 40 μM
PDE3, IC50: >100 μM
PDE4, IC50: 16 nM (in pig aorta)
PDE4, IC50: 2 nM (in eosinophil soluble)
PDE5, IC50: 14 μM
        99.74%
PF-05085727 
PDE2A, IC50: 2 nM
           99.60%
PDE4B-IN-2   
PDE4B, IC50: 15 nM
PDE4D, IC50: 1.7 μM
         99.21%
Glaucine   
PDE4
         99.57%
Vardenafil hydrochloride
PDE1, IC50: 180 nM
 
PDE3, IC50: >1000 nM
PDE4, IC50: >1000 nM
PDE5, IC50: 0.7 nM
PDE6, IC50: 11 nM
       99.79%
Orismilast   
PDE4B3, IC50: 3 nM
PDE4D7, IC50: 3 nM
PDE4D5, IC50: 3 nM
PDE4B2, IC50: 6 nM
PDE4D3, IC50: 8 nM
PDE4D4, IC50: 8 nM
PDE4D1, IC50: 9 nM
PDE4D2, IC50: 9 nM
PDE4A4, IC50: 11 nM
PDE4B1, IC50: 16 nM
PDE4A1, IC50: 16 nM
PDE4A10, IC50: 52 nM
PDE4C2, IC50: 104 nM
         99.37%
Zardaverine  
PDE3
PDE4
         98.64%
PF-04449613       
PDE9A, IC50: 22 nM
     99.83%
ONO-8430506            
Autotaxin
99.68%
Sp-cAMPS sodium salt  
PDE3A, Ki: 47.6 μM
     
PDE10 GAF domain, EC50: 50 μM
    99.45%
Pimobendan  
PDE3
          99.82%
Mirodenafil    
PDE5
        99.70%
Fenspiride hydrochloride  
PDE3
PDE4
PDE5
        99.11%
PF-06445974   
PDE4B, IC50: <1 nM
PDE4D, IC50: 36 nM
PDE4A, IC50: 4.7 nM
PDE4C, IC50: 17 nM
         98.23%
TyK2-IN-2   
PDE4, IC50: 62 nM
         98.64%
Drotaverine hydrochloride   
PDE4
         99.65%
Roflupram   
PDE4, IC50: 26.2 nM
         99.45%
Tanimilast   
PDE4, IC50: 0.026 nM
         99.49%
Tovinontrine
PDE1A3, : 88.4 nM
PDE1B, : 8.48 nM
PDE1C, : 12.2 nM
   
PDE5A2, : 81.9 nM
  
PDE9A1, : 8.19 nM
PDE9A2, : 9.99 nM
     99.83%
Enoximone  
PDE3/PDE Ⅲ, IC50: 5.9 μM
PDE4A, IC50: 21.1 μM (myocardial PDE4A)
         99.91%
Etazolate hydrochloride   
PDE4, IC50: 2 μM
         98.00%
Irsogladine   
PDE4
         99.97%
TMX-4113     
PDE6D
       99.08%
BRD9500  
PDE3A, IC50: 10 nM
PDE3B, IC50: 27 nM
          99.46%
OR-1896  
PDE3/PDE Ⅲ
          99.03%
Lodenafil    
PDE5
        99.94%
Udenafil    
PDE5
        99.67%
TAK-915
PDE1A, IC50: 2497 nM
PDE2A, IC50: 0.61 nM
           99.74%
BAY 73-6691       
PDE9
     99.84%
Osoresnontrine
PDE1C, IC50: 1 μM
PDE1A, IC50: 1.4 μM
      
PDE9A, IC50: 52 nM
     99.88%
PDE1-IN-2
PDE1A, IC50: 164 nM
PDE1B, IC50: 140 nM
PDE1C, IC50: 6 nM
            ≥98.0%
ML-030   
PDE4
         99.50%
(Rac)-Apremilast   
hPDE4D, IC50: 0.3 nM
         99.53%
Olprinone
PDE1, IC50: 150 μM
PDE2, IC50: 100 μM
PDE3, IC50: 0.35 μM
PDE4, IC50: 14 μM
         99.29%
Autotaxin-IN-3            
Autotaxin, IC50: 2.4 nM
98.24%
PAT-505            
Autotaxin, IC50: 2 nM (In Hep3B cells)
Autotaxin, IC50: 9.7 nM (In human blood )
Autotaxin, IC50: 62 nM (In mouse plasma)
99.47%
CM-675    
PDE5, IC50: 114 nM nM
        99.53%
Theophylline (Standard)  
PDE3
          99.99%
Nortadalafil    
PDE5
        99.71%
Oglemilast   
PDE4D3, IC50: .5 nM
         98.00%
Vardenafil hydrochloride trihydrate
PDE1, IC50: 180 nM
 
PDE3, IC50: >1000 nM
PDE4, IC50: >1000 nM
PDE5, IC50: 0.7 nM
PDE6, IC50: 11 nM
       99.67%
PDE7-IN-3      
PDE7
      99.94%
DSR-141562
PDE1
            99.98%
GSK356278   
PDE4A, pIC50: 8.6
PDE4B, pIC50: 8.8
PDE4D, pIC50: 8.7
         99.82%
MY-5445   
PDE4, IC50: 37 μM
PDE5, IC50: 6.7 μM
PDE5, Ki: 1.3 μM
        99.86%
PDE9-IN-1       
PDE9A, IC50: 8.7 nM
     99.70%
K134 
PDE2
PDE3
          99.84%
Thioquinapiperifil dihydrochloride
PDE1, IC50: 380 nM
PDE2, IC50: 670 nM
PDE3, IC50: 38 nM
PDE4, IC50: 800 nM
PDE5, IC50: 0.074 nM
        99.22%
Mardepodect hydrochloride        
PDE10
    99.94%
PDE4B-IN-3   
PDE4B, IC50: .94 μM
         99.37%
AN3199   
PDE4, IC50: 94.5 nM
         99.76%
LEO 39652   
PDE4D, IC50: 3.8 nM
PDE4A, IC50: 1.2 nM
PDE4B, IC50: 1.2 nM
PDE4C2, IC50: 3.0 nM
         99.51%
Dovramilast   
PDE4
PDE4
         99.83%
N-Methylbenzamide        
PDE10A
    99.93%
Motapizone  
PDE3
          
Robustine    
PDE5A
        99.97%
CI-1044   
PDE4A5, IC50: 0.29 μM
PDE4B2, IC50: 0.08 μM
PDE4C2, IC50: 0.56 μM
PDE4D3, IC50: 0.09 μM
         98.02%
Sildenafil-d3    
PDE5
        99.79%
PF-00489791    
PDE5A, IC50: 5 nM
        99.70%
Hcyb1 
PDE2
           98.20%
PDE5-IN-4    
PDE5
        99.60%
BAY-7081       
PDE9A, IC50: 15 nM
     98.00%
K-Ras-PDEδ-IN-1   
PDE4, Kd: 8.3 nM
         99.62%
TPN171    
PDE5, IC50: 0.62 nM
        98.10%
PDE12-IN-3          
PDE12, pXC50: 7.68
  98.02%
Autotaxin modulator 1            
Autotaxin
99.40%
ATX inhibitor 5            
Autotaxin
99.20%
ent-Tadalafil    
PDE5, IC50: 10 μM
        98.17%
PDE5-IN-7
PDE1, IC50: 300 nM
   
PDE5, IC50: 5 nM
        99.59%
Lirimilast   
PDE4, IC50: 42 nM
         98.69%
MBCQ
PDE Ⅰ, IC50: >100 μM
PDE Ⅱ, IC50: >100 μM
PDE Ⅲ, IC50: >100 μM
PDE Ⅳ, IC50: >100 μM
PDE V, IC50: 19 nM
        99.80%
THPP-1        
PDE10
    98.75%
Carbodenafil    
PDE5
        99.63%
Sp-cAMPS  
PDE3A, Ki: 47.6 μM
     
PDE10 GAF domain, EC50: 50 μM
    
PDE7-IN-2      
PDE7A, IC50: 2.1 μM
      ≥99.0%
PQ-10        
PDE10A, IC50: 4.6 nM
    99.77%
MK-0952   
PDE4, IC50: 0.53 nM
         99.71%
Ayanin 
PDE2A
 
PDE4
         98.18%
Gisadenafil besylate
PDE1A, IC50: 9.1 μM
   
PDE5A, IC50: 3.6 nM
        ≥99.0%
PF-8380 hydrochloride            
Autotaxin, IC50: 2.8 nM (In isolated enzyme assay)
98.59%
Tetomilast   
PDE4
         ≥98.0%
PDE10A-IN-2 hydrochloride        
PDE10A, IC50: 2.8 nM
    98.43%
PDE12-IN-1          
PDE12, pIC50: 9.1
  98.85%
PDE2/PDE10-IN-1 
hPDE2A, IC50: 29 nM
 
hPDE4D, IC50: 5890 nM
    
rPDE10A, IC50: 480 nM
hPDE11A, IC50: 6920 nM
   99.88%
FCPR03   
PDE4 catalytic domain, IC50: 60 nM
PDE4B1, IC50: 31 nM
PDE4D7, IC50: 47 nM
         99.82%
BIO-32546            
Autotaxin
99.05%
Olprinone Hydrochloride  
PDE3
          99.85%
RS-25344 hydrochloride
PDE Ⅰ, IC50: >100 μM
PDE Ⅱ, IC50: 160 μM
PDE Ⅲ, IC50: 330 μM
PDE Ⅳ, IC50: 0.28 nM
         99.93%
Atizoram   
PDE4
         
BW-A 78U   
PDE4, IC50: 3 μM
         99.67%
PDE4-IN-4   
PDE4
         
Acetildenafil    
PDE5
        ≥99.0%
Kuraridine    
PDE5, IC50: 0.64 μM
        ≥98.0%
Lodenafil carbonate    
PDE5
        ≥98.0%
Yonkenafil hydrochloride    
PDE5
        99.43%
Sophoflavescenol    
PDE5
        98.78%
EMD 53998  
PDE3
          99.59%
Apremilast-d5   
PDE4
         98.63%
PDE10-IN-1        
PDE10
    99.44%
T-0156
PDE1, IC50: >100 μM
PDE2, IC50: >100 μM
PDE3, IC50: >100 μM
PDE4, IC50: 63 μM
PDE5, IC50: 0.23 nM
PDE6, IC50: 56 nM
       
S32826 disodium            
Autotaxin, IC50: 8.8 nM
98.85%
CDC801   
PDE4
         98.94%
ITI-214 free base
PDE1, Ki: 58 pM
PDE1A, Ki: 33 pM
PDE1B, Ki: 380 pM
PDE1C, Ki: 35 pM
            ≥98.0%
PF-07038124   
PDE4B2, IC50: 0.5 nM
         
LASSBio-1632   
PDE4A
PDE4D
         
PF-04822163
PDE1A, IC50: 2 nM
PDE1B, IC50: 2.4 nM
PDE1C, IC50: 7 nM
PDE2A, IC50: 5895 nM
PDE3A, IC50: >30000 nM
PDE4D3, IC50: 7620 nM
PDE5A1, IC50: >30000 nM
 
PDE7B, IC50: >29800 nM
PDE9A1, IC50: >30000 nM
PDE10A1, IC50: 252 nM
PDE11A4, IC50: 8257 nM
   
Vardenafil dihydrochloride
PDE1, IC50: 180 nM
   
PDE5, IC50: 0.7 nM
PDE6, IC50: 11 nM
       
Avanafil dibenzenesulfonate
PDE1, IC50: 53000 nM
PDE2, IC50: 51000 nM
 
PDE4, IC50: 5700 nM
PDE5, IC50: 5.2 nM
PDE6, IC50: 630 nM
PDE7, IC50: 27000 nM
 
PDE10, IC50: 6200 nM
    
TPN729MA
PDE1, IC50: 566 nM
  
PDE4, IC50: 834 nM
PDE5, IC50: 2.28 nM
PDE6, IC50: 45.2 nM
   
PDE11, IC50: 6090 nM
   99.45%
TPN729
PDE1, IC50: 566 nM
  
PDE4, IC50: 834 nM
PDE5, IC50: 2.28 nM
PDE6, IC50: 45.2 nM
   
PDE11, IC50: 6090 nM
   
Autotaxin-IN-4            
Autotaxin
PDE5-IN-2 
PDE2A, IC50: 106 nM
 
PDE4D2, IC50: 43 nM
PDE5A1, IC50: 0.31 nM
PDE6C, IC50: 1.2 nM
  
PDE10A, IC50: 46 nM
    
Theophylline monohydrate  
PDE3
          
MT-3014        
human PDE 10A, IC50: 0.062 nM
bovine PDE 10A, IC50: 0.09 nM
    
ID11916    
PDE5
        
Sp-cAMPS triethylamine  
PDE3A, Ki: 47.6 μM
     
PDE10 GAF domain, EC50: 50 μM
    
PDE10A-IN-5        
PDE10A, IC50: 3.5 nM
    
(S)-C33
PDE1B, IC50: 554 ± 64 nM
PDE2A, IC50: 2.4 ± 0.5 μM
 
PDE4D2, IC50: 1.3 ± 0.1 μM
PDE5A1, IC50: 366 ± 38 nM
  
PDE9A, IC50: 11 ± 4 nM
PDE10A1, IC50: 2.3 ± 0.3 μM
    99.46%
Menabitan dihydrochloride       
PDE9
     
P7–2302   
PDE4B, IC50: 77.3 nM
  
PDE7, IC50: 0.18 nM
      
Gemlapodect        
PDE10A
    
PDE11-IN-1         
PDE11
   98.23%
PDE4-IN-6   
PDE4B, IC50: 0.125 μM
PDE4D, IC50: 0.43 μM
         
PDE4-IN-15   
PDE4
         
Meribendan  
PDE Ⅲ
          
Thioquinapiperifil
PDE1, IC50: 380 nM
PDE2, IC50: 670 nM
PDE3, IC50: 38 nM
PDE4, IC50: 800 nM
PDE5, IC50: 0.074 nM
        
Deltazinone 1     
PDEδ, Kd: 8 nM
       
PDE11A4-IN-1         
PDE11A4, IC50: 12 nM
   
S32826            
Autotaxin, IC50: 8.8 nM
PDE5-IN-3    
PDE5, IC50: 1.57 nM
        
Imazodan hydrochloride  
PDE3/PDE Ⅲ
          
PDE5-IN-13
PDE1C, IC50: 10478 nM
PDE2A, IC50: 3378 nM
PDE3A, IC50: >100000 nM
PDE4D2, IC50: 53294 nM
PDE5A, IC50: 3 nM
PDE6C, IC50: 20 nM
PDE7A, IC50: 25746 nM
PDE9A2, IC50: >100000 nM
PDE10A2, IC50: 21160 nM
PDE11A, IC50: >100000 nM
 
PDE8A1, IC50: >100000 nM
 
Z21090   
PDE4, IC50: 37.4 nM
         
Menabitan       
PDE9
     
PDE4B/D-IN-3   
PDE4B, IC50: 0.071 nM
PDE4D, IC50: 0.09 nM
         
PDE4-IN-24   
PDE4D, IC50: 0.57 nM
         
PF-03049423 free base    
PDE5A
        
ATX inhibitor 18            
Autotaxin, IC50: 24.2 nM
PDE4-IN-12   
PDE4D2, IC50: 3.51 nM
PDE4B2, IC50: 9.51 nM
PDE5A1, IC50: 1.24 μM
 
PDE7A, IC50: 15 nM
 
PDE10A, IC50: 1.02 μM
  
PDE8A1, IC50: 194 nM
 
FR-229934    
PDE V
        98.65%
Gisadenafil
PDE1A, IC50: 9.1 μM
   
PDE5A, IC50: 3.6 nM
        
(R)-Irsenontrine       
PDE9, IC50: 0.041 μM
     99.00%
PDE5-IN-9    
PDE5
        ≥98.0%
Tofimilast   
PDE4, IC50: 0.14 μM
         
ATX inhibitor 20            
Autotaxin, IC50: 2.3 ± 0.31 nM
ATX inhibitor 15            
Autotaxin, IC50: 2.17 nM
PDE5/HDAC-IN-1    
PDE5, IC50: 46.3 nM
        
Norbraylin   
PDE4D2, IC50: 7.15 μM
         
PDE4-IN-18   
PDE4, IC50: 1.55 μM
         
ATX inhibitor 12            
Autotaxin, IC50: 1.72 nM
PDE4-IN-26   
PDE4A, IC50: 89.7 nM
PDE4B, IC50: 48.8 nM
PDE4D, IC50: 5.9 nM
         
Anagrelide hydrochloride monohydrate  
PDE3
          
ICI-63197
PDE Ⅰ, Ki: 487 μM
PDE Ⅱ, Ki: >1000 μM
PDE3/PDE Ⅲ, Ki: 9 μM
PDE Ⅳ, Ki: 10 μM
         99.14%
PDE3B-IN-1  
PDE3B, IC50: 6.5 μM
          
PDE4B/D-IN-4   
PDE4B, IC50: 5.50 nM
PDE4D, IC50: 6.81 nM
         
PDE4-IN-11   
PDE4
         
Phosphodiesterase-IN-2        
PDE10A, IC50: 11.9 nM
    
ATX inhibitor 19            
Autotaxin, IC50: 156 ± 19.8 nM
ATX inhibitor 14            
Autotaxin, IC50: 0.41 nM
PDE2A-IN-1 
PDE2
           
Arofylline   
PDE4
         
Ilexsaponin B2
PDEI, IC50: 477.5 μM
   
PDE5, IC50: 48.8 μM
        
Autotaxin-IN-1            
Autotaxin, IC50: 2 nM
ATX inhibitor 8            
Autotaxin
BC8-15   
PDE4A, IC50: 0.22 μM
  
PDE7A, IC50: 6.46 μM
    
PDE8A, IC50: 0.28 μM
 
PDE7A-IN-1      
PDE7A, IC50: 3.7 nM
      
Icariin (Standard)   
PDE4
PDE5
        
Z19153   
PDE4B1, IC50: 110 nM
PDE4D7, IC50: 1160 nM
         
PDE4B/D-IN-2   
PDE4B, IC50: 0.023 nM
PDE4D, IC50: 0.066 nM
         
MK-0873   
PDE4
         
AGS-16C3F  
PDE3
          
PDE5-IN-10    
PDE5, IC50: 20 nM
        
JNJ-42314415        
human PDE 10A, Ki: 35 nM
    
1,3,5-Trihydroxy-4-prenylxanthone    
PDE5, IC50: 3 μM
        
PDE4B/D-IN-1   
PDE4B, IC50: 0.07 nM
PDE4D, IC50: 0.09 nM
         
Mesembrine   
PDE4B, IC50: 7.8 μM
         
12-epi-Tadalafil    
PDE5, IC50: 0.09 μM
        
PDE1-IN-7
PDEI, IC50: 10 nM
            
CDP-840   
PDE4
         
Autotaxin-IN-5            
Autotaxin
Fenspiride  
PDE3
PDE4
PDE5
        
PDE4D inhibitor 1
PDE1B2, IC50: >10000 nM
PDE2A, IC50: >10000 nM
PDE3A, IC50: >10000 nM
PDE4B1, IC50: 5.3 nM
PDE4D2, IC50: 8.6 nM
PDE4A10, IC50: 100 nM
PDE4C1, IC50: 747 nM
PDE5A1, IC50: 1730 nM
 
PDE7A1, IC50: 5913 nM
PDE9A2, IC50: >10000 nM
PDE10A2, IC50: 1953 nM
  
PDE8A1, IC50: >10000 nM
 
PDE4-IN-5   
PDE4
         
Autotaxin-IN-6            
Autotaxin, IC50: 30 nM
MHC00188            
Autotaxin
ATX inhibitor 11            
Autotaxin, IC50: 2.7 ± 1 nM
PDE4-IN-8   
PDE4B2, IC50: 0.93 nM
         
Avanafil-13C,d3
PDE1
            
Mesopram   
PDE4
         98.80%
Deacetylsclerotiorin   
PDE4, IC50: 2.8 μM
         
Theophylline sodium acetate  
PDE3
          
PDE4-IN-13   
PDE4, IC50: 1.56 μM
         
Talaroterphenyl A   
PDE4, IC50: 1.2 μM
         
TC-E 5005 
PDE2A, IC50: 239 nM
PDE3A, IC50: 3700 nM
 
PDE5A, IC50: 919 nM
 
PDE7B, IC50: 3100 nM
 
PDE10A, IC50: 7.28 nM
hPDE11A, IC50: 779 nM
   
PDE4B/7A-IN-1   
PDE4
  
PDE7
      
AChE/PDE4-IN-1   
PDE4, IC50: 1.88 μM
         
PDE4B/7A-IN-2   
PDE4
  
PDE7
      
PDE5-IN-5    
PDE5, IC50: 2.0 nM
        
ATX inhibitor 21            
Autotaxin, IC50: 3490 ± 170 nM
Z21115   
PDE4D7, IC50: 10.5 nM
PDE4D, IC50: 65.7 nM
PDE4B, IC50: 64.4 nM
         
L-869298   
PDE4A, IC50: 0.5 nM
         
PF-07038124 hydrochloride   
PDE4, : 0.5 nM
         
PDE5-IN-12    
PDE5, IC50: 22 nM
        
PF-03049423    
PDE5A
        
PDE1-IN-4
PDE1C, IC50: 10 ± 3 nM
PDE1A, IC50: 145 nM
PDE1B, IC50: 354 nM
PDE2A, IC50: 5130 nM
PDE3A, IC50: >10000 nM
PDE4B2, IC50: 619 nM
PDE4D2, IC50: 948 nM
PDE5A1, IC50: 1810 nM
  
PDE9A2, IC50: >10000 nM
PDE10A, IC50: 1310 nM
    
PDE4-IN-19   
PDE4B1, IC50: <10 nM
PDE4D3, IC50: 10-100 nM
         
PDE4-IN-10   
PDE4B, IC50: 7.01 ± 1.0 μM
         
PDE1-IN-8
PDE1C, IC50: 11 nM
PDE1A, IC50: 263 nM
PDE1B, IC50: 357 nM
PDE2A, IC50: 1820 nM
PDE3A, IC50: 5164 nM
PDE4D, IC50: 3006 nM
PDE5A, IC50: 681 nM
 
PDE7A, IC50: 2093 nM
PDE9A, IC50: 4617 nM
PDE10A, IC50: 2394 nM
  
PDE8A, IC50: 3729 nM
 
Pumafentrine  
PDE3
PDE4
         
SAR156497  
PDE3, IC50: 4 μM
          
ATX inhibitor 22            
Autotaxin, IC50: 218 nM
CP-220629   
PDE4, IC50: 0.44 μM
         
AMG580        
PDE10A
    
UK-500001   
PDE4D3, IC50: 0.28 nM
PDE4B2, IC50: 22.8 nM
PDE4A4, IC50: 26.1 nM
PDE4C2, IC50: 217 nM
         
MEY-003            
Autotaxin
N-Desethyl-N-methyl vardenafil    
PDE5, IC50: 0.14 μM
        
Xanthoanthrafil    
PDE5, : 3.95 ng/mL
        
SCH 51866
PDE1, IC50: 70 nM
   
PDE5, IC50: 60 nM
        
CM-545    
PDE5, pIC50: 7.47
        
AWD 12-281   
PDE4, IC50: 9.7 nM
         
RS14203   
PDE4
         
BML-288 
PDE2, IC50: 40 nM
           
UK 357903    
PDE5, IC50: 1.7 nM
PDE6, IC50: 714 nM
       
PDE4-IN-25   
PDE4, IC50: 0.1 μM
         
LEO 29102   
PDE4, IC50: 5 nM
         
Irsogladine maleate   
PDE4
         
PF-06815189 
PDE2A, IC50: 0.4 nM
           
ONO-6126   
PDE4
         
SCH 351591   
PDE4, IC50: 58 nM
         
JNJ-10258859
PDE1, Ki: >100 μM
PDE2, Ki: 25.33±5.53 μM
PDE3, Ki: 9.67±1.95 μM
PDE4, Ki: 5.01±1.88 μM
PDE5, Ki: 0.23±0.03 nM
        
MMPX
PDEI
            
BMS-341400 mesylate    
PDE5, IC50: 0.3 nM
        
L791943   
PDE4