1. Academic Validation
  2. Calumenin relieves cardiac injury by inhibiting ERS-initiated apoptosis during viral myocarditis

Calumenin relieves cardiac injury by inhibiting ERS-initiated apoptosis during viral myocarditis

  • Int J Clin Exp Pathol. 2017 Jul 1;10(7):7277-7284.
Yu Wang 1 2 Ying Sun 3 Yao Fu 1 2 Xin Guo 1 2 Jie Long 1 4 Li-Ying Xuan 1 Cheng-Xi Wei 1 2 Ming Zhao 1 4 2
Affiliations

Affiliations

  • 1 Inner Mongolia University for The Nationalities Tongliao, Inner Mongolia, P. R. China.
  • 2 Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System Tongliao, Inner Mongolia, P. R. China.
  • 3 Radiation Center, Beijing Shijitan Hospital of Capital Medical University Beijing, P. R. China.
  • 4 Affiliated Hospital of Inner Mongolia University for Nationalities Tongliao, Inner Mongolia, P. R. China.
PMID: 31966567
Abstract

Viral myocarditis (VMC) is a common disease causing heart failure (HF) for which no specific treatments are available. As Apoptosis of cardiomyoctes is a hallmark of VMC and HF, strategies targeting Apoptosis are an effective way of prevention and treatment of HF. Recent studies found endoplasmic reticulum stress (ERS) reaction is a new signal transduction pathway mediating Apoptosis. Calumenin protein (CP) is located within the endoplasmic reticulum CA2+ binding proteins, and is important in ER-initiated Apoptosis. The aim of this study was to investigate whether the function of CP was influenced in cardiomyocytes infected by coxsackievirus B3. The expression of CP was down-regulated in cardiomyocytes infected by coxsackievirus B3. TUNEL studies showed that Apoptosis was increased in CP-deficient and ΔCP-mutant cardiomyocytes infected by coxsackievirus B3. Additionally, ERS-associated proteins (GRP78, p-PERK, p-eIF2α, ATF4 and CHOP) were up-regulated in coxsackievirus B3-infected CP-deficient and ΔCP-mutant cardiomyocytes compared to wild type control cells. These results suggested ER-initiated Apoptosis was induced by coxsackievirus B3-infected cardiomyocytes and caused Apoptosis through ER stress. CP can relieve ERS-initiated Apoptosis in viral myocarditis.

Keywords

ERS-initiated apoptosis; Endoplasmic reticulum stress; calumenin protein; coxsackievirus B3; heart failure (HF).

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