2. Academic Validation
  3. A β-allyl carbamate fluorescent probe for vicinal dithiol proteins

A β-allyl carbamate fluorescent probe for vicinal dithiol proteins

  • Chem Commun (Camb). 2020 Mar 5;56(19):2857-2860. doi: 10.1039/c9cc09841k.
Lanning Zhao 1,  Feifei Bai 1,  Fan Chen 1,  Menghuan Guo 2,  Lu Gan 3,  Hong Zhang 3,  Jianguo Fang 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China. fangjg@lzu.edu.cn.
  • 2 School of Pharmacy Lanzhou University, Lanzhou, Gansu 730000, China.
  • 3 Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China and Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, Gansu 730000, China and University of Chinese Academy of Sciences, Beijing 100039, China.
PMID: 32031544 DOI: 10.1039/c9cc09841k
Abstract

The first β-allyl carbamate fluorescent probe, AC-green, was reported for specifically imaging vicinal dithiol proteins (VDPs) in living systems. The probe displays low toxicity and features high sensitivity and fast response towards VDPs. A drastic loss of VDPs in a Parkinson's model was disclosed by AC-green, linking the fluctuation of VDP levels to Parkinson's disease for the first time. The structural novelty and favorable properties of AC-green will advance the development of novel VDP probes.

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